NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.
| Uniprot primary ID | P35439 |
| PDB ID | 2A5T 4NF4 4NF6 1Y1M 4NF5 1PB9 4NF8 1PB7 1Y20 3Q41 4PE5 1Y1Z 1PBQ 4KCC 4KFQ 1PB8 |
| DrugBank ID | |
| BioGrid ID | 246573 |
| GuidetoPHARMACOLOGY ID | 455 |
| PharmGKB ID | |
| KEGG ID | rno:24408 |
| DIP ID | DIP-674N |
| STRING ID | 10116.ENSRNOP00000029227 |
| IntAct ID | P35439 |
| DMDM | |
| BRENDA | |
| Reactome | R-RNO-3928662 R-RNO-438066 R-RNO-5673001 R-RNO-442729 R-RNO-442982 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 24408 |
| BindingDB | P35439 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.924 | 0.005 | 0.956 | 0.000 | 0.940 | 0.000 | 0.940 | 0.000 | 0.980 | 0.000 | 0.886 | 0.005 | Download |
| Estate fingerprints | 0.869 | 0.006 | 0.885 | 0.003 | 0.877 | 0.005 | 0.877 | 0.005 | 0.940 | 0.000 | 0.756 | 0.007 | Download |
| MACCS fingerprints | 0.906 | 0.005 | 0.918 | 0.005 | 0.912 | 0.004 | 0.912 | 0.004 | 0.960 | 0.000 | 0.824 | 0.005 | Download |
| Daylight fingerprints | 0.858 | 0.006 | 0.906 | 0.005 | 0.882 | 0.004 | 0.880 | 0.005 | 0.950 | 0.000 | 0.769 | 0.009 | Download |
| ECFP2 fingerprints | 0.960 | 0.000 | 0.960 | 0.004 | 0.960 | 0.000 | 0.960 | 0.000 | 0.990 | 0.000 | 0.920 | 0.000 | Download |
| ECFP4 fingerprints | 0.974 | 0.005 | 0.986 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 1.000 | 0.000 | 0.960 | 0.000 | Download |
| ECFP6 fingerprints | 0.974 | 0.005 | 0.986 | 0.004 | 0.980 | 0.000 | 0.980 | 0.000 | 1.000 | 0.000 | 0.962 | 0.004 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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