Target name

P35439: Glutamate receptor ionotropic, NMDA 1


  Protein function

NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.

  Database links

Uniprot primary ID P35439
PDB ID 2A5T 4NF4 4NF6 1Y1M 4NF5 1PB9 4NF8 1PB7 1Y20 3Q41 4PE5 1Y1Z 1PBQ 4KCC 4KFQ 1PB8
DrugBank ID
BioGrid ID 246573
GuidetoPHARMACOLOGY ID 455
PharmGKB ID
KEGG ID rno:24408
DIP ID DIP-674N
STRING ID 10116.ENSRNOP00000029227
IntAct ID P35439
DMDM
BRENDA
Reactome R-RNO-3928662 R-RNO-438066 R-RNO-5673001 R-RNO-442729 R-RNO-442982
SignaLink
BioCyc
Entrez Gene (Gene ID) 24408
BindingDB P35439

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.924 0.005 0.956 0.000 0.940 0.000 0.940 0.000 0.980 0.000 0.886 0.005 Download
Estate fingerprints 0.869 0.006 0.885 0.003 0.877 0.005 0.877 0.005 0.940 0.000 0.756 0.007 Download
MACCS fingerprints 0.906 0.005 0.918 0.005 0.912 0.004 0.912 0.004 0.960 0.000 0.824 0.005 Download
Daylight fingerprints 0.858 0.006 0.906 0.005 0.882 0.004 0.880 0.005 0.950 0.000 0.769 0.009 Download
ECFP2 fingerprints 0.960 0.000 0.960 0.004 0.960 0.000 0.960 0.000 0.990 0.000 0.920 0.000 Download
ECFP4 fingerprints 0.974 0.005 0.986 0.000 0.980 0.000 0.980 0.000 1.000 0.000 0.960 0.000 Download
ECFP6 fingerprints 0.974 0.005 0.986 0.004 0.980 0.000 0.980 0.000 1.000 0.000 0.962 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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