Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
| Uniprot primary ID | P35462 |
| PDB ID | 3PBL |
| DrugBank ID | DB00502 DB01239 DB01238 DB01100 DB06148 DB00734 DB06288 |
| BioGrid ID | 108148 |
| GuidetoPHARMACOLOGY ID | 216 |
| PharmGKB ID | PA27479 |
| KEGG ID | hsa:1814 |
| DIP ID | DIP-5976N |
| STRING ID | 9606.ENSP00000373169 |
| IntAct ID | |
| DMDM | 1169206 |
| BRENDA | |
| Reactome | R-HSA-418594 R-HSA-390651 |
| SignaLink | P35462 |
| BioCyc | |
| Entrez Gene (Gene ID) | 1814 |
| BindingDB | P35462 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.860 | 0.000 | 0.800 | 0.005 | 0.830 | 0.000 | 0.838 | 0.004 | 0.900 | 0.000 | 0.663 | 0.005 | Download |
| Estate fingerprints | 0.868 | 0.004 | 0.752 | 0.000 | 0.810 | 0.000 | 0.820 | 0.000 | 0.880 | 0.000 | 0.622 | 0.004 | Download |
| MACCS fingerprints | 0.890 | 0.000 | 0.730 | 0.000 | 0.810 | 0.000 | 0.830 | 0.000 | 0.900 | 0.000 | 0.630 | 0.000 | Download |
| Daylight fingerprints | 0.740 | 0.000 | 0.760 | 0.000 | 0.750 | 0.000 | 0.750 | 0.000 | 0.800 | 0.000 | 0.500 | 0.000 | Download |
| ECFP2 fingerprints | 0.931 | 0.003 | 0.889 | 0.004 | 0.910 | 0.000 | 0.910 | 0.000 | 0.970 | 0.000 | 0.821 | 0.003 | Download |
| ECFP4 fingerprints | 0.908 | 0.004 | 0.932 | 0.000 | 0.920 | 0.000 | 0.920 | 0.000 | 0.970 | 0.000 | 0.840 | 0.000 | Download |
| ECFP6 fingerprints | 0.850 | 0.000 | 0.950 | 0.005 | 0.900 | 0.000 | 0.895 | 0.005 | 0.970 | 0.000 | 0.803 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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