Target name

P35462: D(3) dopamine receptor


  Protein function

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.

  Database links

Uniprot primary ID P35462
PDB ID 3PBL
DrugBank ID DB00502 DB01239 DB01238 DB01100 DB06148 DB00734 DB06288
BioGrid ID 108148
GuidetoPHARMACOLOGY ID 216
PharmGKB ID PA27479
KEGG ID hsa:1814
DIP ID DIP-5976N
STRING ID 9606.ENSP00000373169
IntAct ID
DMDM 1169206
BRENDA
Reactome R-HSA-418594 R-HSA-390651
SignaLink P35462
BioCyc
Entrez Gene (Gene ID) 1814
BindingDB P35462

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.860 0.000 0.800 0.005 0.830 0.000 0.838 0.004 0.900 0.000 0.663 0.005 Download
Estate fingerprints 0.868 0.004 0.752 0.000 0.810 0.000 0.820 0.000 0.880 0.000 0.622 0.004 Download
MACCS fingerprints 0.890 0.000 0.730 0.000 0.810 0.000 0.830 0.000 0.900 0.000 0.630 0.000 Download
Daylight fingerprints 0.740 0.000 0.760 0.000 0.750 0.000 0.750 0.000 0.800 0.000 0.500 0.000 Download
ECFP2 fingerprints 0.931 0.003 0.889 0.004 0.910 0.000 0.910 0.000 0.970 0.000 0.821 0.003 Download
ECFP4 fingerprints 0.908 0.004 0.932 0.000 0.920 0.000 0.920 0.000 0.970 0.000 0.840 0.000 Download
ECFP6 fingerprints 0.850 0.000 0.950 0.005 0.900 0.000 0.895 0.005 0.970 0.000 0.803 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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