Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
| Uniprot primary ID | P35463 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | |
| KEGG ID | ssc:414911 |
| DIP ID | |
| STRING ID | 9823.ENSSSCP00000010120 |
| IntAct ID | |
| DMDM | |
| BRENDA | |
| Reactome | R-SSC-375276 R-SSC-416476 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 414911 |
| BindingDB | P35463 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.880 | 0.008 | 0.980 | 0.004 | 0.930 | 0.005 | 0.925 | 0.007 | 0.987 | 0.005 | 0.863 | 0.008 | Download |
| Estate fingerprints | 0.773 | 0.005 | 0.807 | 0.004 | 0.790 | 0.000 | 0.784 | 0.005 | 0.904 | 0.005 | 0.577 | 0.005 | Download |
| MACCS fingerprints | 0.801 | 0.007 | 0.933 | 0.005 | 0.867 | 0.005 | 0.858 | 0.004 | 0.968 | 0.004 | 0.741 | 0.006 | Download |
| Daylight fingerprints | 0.906 | 0.005 | 0.956 | 0.003 | 0.931 | 0.003 | 0.930 | 0.000 | 0.980 | 0.000 | 0.867 | 0.005 | Download |
| ECFP2 fingerprints | 0.987 | 0.005 | 0.975 | 0.000 | 0.981 | 0.003 | 0.986 | 0.005 | 1.000 | 0.000 | 0.968 | 0.004 | Download |
| ECFP4 fingerprints | 0.974 | 0.005 | 0.988 | 0.004 | 0.981 | 0.003 | 0.981 | 0.003 | 1.000 | 0.000 | 0.969 | 0.003 | Download |
| ECFP6 fingerprints | 0.960 | 0.005 | 0.998 | 0.000 | 0.979 | 0.003 | 0.979 | 0.003 | 1.000 | 0.000 | 0.960 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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