This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.
| Uniprot primary ID | P35563 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 373 |
| PharmGKB ID | |
| KEGG ID | rno:79246 |
| DIP ID | |
| STRING ID | 10116.ENSRNOP00000008965 |
| IntAct ID | |
| DMDM | |
| BRENDA | |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 79246 |
| BindingDB | P35563 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.834 | 0.013 | 0.844 | 0.013 | 0.839 | 0.009 | 0.839 | 0.009 | 0.920 | 0.000 | 0.682 | 0.016 | Download |
| Estate fingerprints | 0.821 | 0.011 | 0.673 | 0.009 | 0.747 | 0.007 | 0.763 | 0.008 | 0.823 | 0.005 | 0.498 | 0.018 | Download |
| MACCS fingerprints | 0.899 | 0.007 | 0.673 | 0.011 | 0.786 | 0.005 | 0.810 | 0.007 | 0.873 | 0.005 | 0.591 | 0.014 | Download |
| Daylight fingerprints | 0.791 | 0.010 | 0.803 | 0.009 | 0.797 | 0.005 | 0.797 | 0.005 | 0.845 | 0.005 | 0.596 | 0.012 | Download |
| ECFP2 fingerprints | 0.884 | 0.011 | 0.784 | 0.012 | 0.834 | 0.011 | 0.843 | 0.009 | 0.923 | 0.007 | 0.677 | 0.020 | Download |
| ECFP4 fingerprints | 0.899 | 0.007 | 0.865 | 0.012 | 0.882 | 0.006 | 0.884 | 0.007 | 0.960 | 0.000 | 0.765 | 0.012 | Download |
| ECFP6 fingerprints | 0.858 | 0.012 | 0.940 | 0.008 | 0.899 | 0.009 | 0.897 | 0.008 | 0.969 | 0.003 | 0.804 | 0.013 | Download |
| Positive dataset | Negative dataset |
The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: jiedong@csu.edu.cn
 |
 |
 |
 |
 |
 |