Details-Calcnet-TargetNet

Target name

P35563: 5-hydroxytryptamine receptor 3A

Protein function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Database links

Uniprot primary ID	P35563
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID	373
PharmGKB ID
KEGG ID	rno:79246
DIP ID
STRING ID	10116.ENSRNOP00000008965
IntAct ID
DMDM
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID)	79246
BindingDB	P35563

Model Performance Metrics

Fingerprint type	Sensitivity	SEN_std	Specificity	SPE_std	Accuracy	ACC_std	F1-score	F1-score_std	AUC	AUC_std	MCC	MCC_std	Download model
FP2 fingerprints	0.834	0.013	0.844	0.013	0.839	0.009	0.839	0.009	0.920	0.000	0.682	0.016	Download
Estate fingerprints	0.821	0.011	0.673	0.009	0.747	0.007	0.763	0.008	0.823	0.005	0.498	0.018	Download
MACCS fingerprints	0.899	0.007	0.673	0.011	0.786	0.005	0.810	0.007	0.873	0.005	0.591	0.014	Download
Daylight fingerprints	0.791	0.010	0.803	0.009	0.797	0.005	0.797	0.005	0.845	0.005	0.596	0.012	Download
ECFP2 fingerprints	0.884	0.011	0.784	0.012	0.834	0.011	0.843	0.009	0.923	0.007	0.677	0.020	Download
ECFP4 fingerprints	0.899	0.007	0.865	0.012	0.882	0.006	0.884	0.007	0.960	0.000	0.765	0.012	Download
ECFP6 fingerprints	0.858	0.012	0.940	0.008	0.899	0.009	0.897	0.008	0.969	0.003	0.804	0.013	Download

Download datasets

Positive dataset

Negative dataset