Target name

P35563: 5-hydroxytryptamine receptor 3A


  Protein function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.

  Database links

Uniprot primary ID P35563
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 373
PharmGKB ID
KEGG ID rno:79246
DIP ID
STRING ID 10116.ENSRNOP00000008965
IntAct ID
DMDM
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 79246
BindingDB P35563

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.834 0.013 0.844 0.013 0.839 0.009 0.839 0.009 0.920 0.000 0.682 0.016 Download
Estate fingerprints 0.821 0.011 0.673 0.009 0.747 0.007 0.763 0.008 0.823 0.005 0.498 0.018 Download
MACCS fingerprints 0.899 0.007 0.673 0.011 0.786 0.005 0.810 0.007 0.873 0.005 0.591 0.014 Download
Daylight fingerprints 0.791 0.010 0.803 0.009 0.797 0.005 0.797 0.005 0.845 0.005 0.596 0.012 Download
ECFP2 fingerprints 0.884 0.011 0.784 0.012 0.834 0.011 0.843 0.009 0.923 0.007 0.677 0.020 Download
ECFP4 fingerprints 0.899 0.007 0.865 0.012 0.882 0.006 0.884 0.007 0.960 0.000 0.765 0.012 Download
ECFP6 fingerprints 0.858 0.012 0.940 0.008 0.899 0.009 0.897 0.008 0.969 0.003 0.804 0.013 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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 E-mail: biomed@csu.edu.cn