Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase.
| Uniprot primary ID | P35610 |
| PDB ID | |
| DrugBank ID | DB01094 DB00973 |
| BioGrid ID | 112529 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA36015 |
| KEGG ID | hsa:6646 |
| DIP ID | |
| STRING ID | 9606.ENSP00000356591 |
| IntAct ID | P35610 |
| DMDM | 33302623 |
| BRENDA | 2.3.1.26 |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 6646 |
| BindingDB | P35610 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.870 | 0.000 | 0.970 | 0.003 | 0.920 | 0.000 | 0.914 | 0.005 | 0.977 | 0.005 | 0.840 | 0.000 | Download |
| Estate fingerprints | 0.841 | 0.003 | 0.781 | 0.003 | 0.811 | 0.003 | 0.818 | 0.004 | 0.890 | 0.000 | 0.625 | 0.005 | Download |
| MACCS fingerprints | 0.847 | 0.005 | 0.913 | 0.000 | 0.880 | 0.000 | 0.874 | 0.005 | 0.950 | 0.000 | 0.759 | 0.003 | Download |
| Daylight fingerprints | 0.804 | 0.005 | 0.836 | 0.000 | 0.820 | 0.000 | 0.820 | 0.000 | 0.820 | 0.000 | 0.645 | 0.005 | Download |
| ECFP2 fingerprints | 0.949 | 0.003 | 0.971 | 0.000 | 0.960 | 0.000 | 0.960 | 0.000 | 0.990 | 0.000 | 0.920 | 0.000 | Download |
| ECFP4 fingerprints | 0.959 | 0.003 | 0.987 | 0.000 | 0.973 | 0.005 | 0.973 | 0.005 | 0.990 | 0.000 | 0.947 | 0.005 | Download |
| ECFP6 fingerprints | 0.947 | 0.005 | 0.993 | 0.003 | 0.970 | 0.000 | 0.970 | 0.000 | 0.990 | 0.000 | 0.944 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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