Target name

P35610: Sterol O-acyltransferase 1


  Protein function

Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase.

  Database links

Uniprot primary ID P35610
PDB ID
DrugBank ID DB01094 DB00973
BioGrid ID 112529
GuidetoPHARMACOLOGY ID
PharmGKB ID PA36015
KEGG ID hsa:6646
DIP ID
STRING ID 9606.ENSP00000356591
IntAct ID P35610
DMDM 33302623
BRENDA 2.3.1.26
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 6646
BindingDB P35610

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.870 0.000 0.970 0.003 0.920 0.000 0.914 0.005 0.977 0.005 0.840 0.000 Download
Estate fingerprints 0.841 0.003 0.781 0.003 0.811 0.003 0.818 0.004 0.890 0.000 0.625 0.005 Download
MACCS fingerprints 0.847 0.005 0.913 0.000 0.880 0.000 0.874 0.005 0.950 0.000 0.759 0.003 Download
Daylight fingerprints 0.804 0.005 0.836 0.000 0.820 0.000 0.820 0.000 0.820 0.000 0.645 0.005 Download
ECFP2 fingerprints 0.949 0.003 0.971 0.000 0.960 0.000 0.960 0.000 0.990 0.000 0.920 0.000 Download
ECFP4 fingerprints 0.959 0.003 0.987 0.000 0.973 0.005 0.973 0.005 0.990 0.000 0.947 0.005 Download
ECFP6 fingerprints 0.947 0.005 0.993 0.003 0.970 0.000 0.970 0.000 0.990 0.000 0.944 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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