Target name

P35869: Aryl hydrocarbon receptor


  Protein function

Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.

  Database links

Uniprot primary ID P35869
PDB ID
DrugBank ID DB01076 DB00499 DB01097 DB01404 DB00393 DB00379
BioGrid ID 106699
GuidetoPHARMACOLOGY ID
PharmGKB ID PA24641
KEGG ID hsa:196
DIP ID DIP-946N
STRING ID 9606.ENSP00000242057
IntAct ID P35869
DMDM 3041653
BRENDA
Reactome
SignaLink P35869
BioCyc
Entrez Gene (Gene ID) 196
BindingDB P35869

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.868 0.012 0.730 0.016 0.799 0.010 0.811 0.011 0.900 0.005 0.602 0.020 Download
Estate fingerprints 0.854 0.013 0.788 0.006 0.821 0.010 0.828 0.008 0.900 0.000 0.643 0.018 Download
MACCS fingerprints 0.820 0.000 0.762 0.009 0.791 0.003 0.799 0.003 0.854 0.005 0.582 0.006 Download
Daylight fingerprints 0.643 0.015 0.773 0.009 0.708 0.004 0.690 0.008 0.778 0.006 0.421 0.010 Download
ECFP2 fingerprints 0.943 0.007 0.713 0.011 0.828 0.008 0.847 0.007 0.919 0.006 0.677 0.015 Download
ECFP4 fingerprints 0.953 0.011 0.697 0.017 0.825 0.008 0.845 0.008 0.929 0.007 0.674 0.015 Download
ECFP6 fingerprints 0.938 0.008 0.708 0.009 0.823 0.008 0.841 0.006 0.924 0.005 0.662 0.015 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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