Target name

P35916: Vascular endothelial growth factor receptor 3


  Protein function

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.

  Database links

Uniprot primary ID P35916
PDB ID 4BSK 4BSJ
DrugBank ID DB09079 DB09078 DB06626 DB01268 DB06589 DB08896 DB00398
BioGrid ID 108612
GuidetoPHARMACOLOGY ID 1814
PharmGKB ID PA28183
KEGG ID hsa:2324
DIP ID DIP-5739N
STRING ID 9606.ENSP00000261937
IntAct ID P35916
DMDM 357529070
BRENDA 2.7.10.1
Reactome R-HSA-195399
SignaLink P35916
BioCyc
Entrez Gene (Gene ID) 2324
BindingDB P35916

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.754 0.013 0.890 0.011 0.822 0.006 0.810 0.009 0.905 0.005 0.650 0.011 Download
Estate fingerprints 0.727 0.011 0.721 0.006 0.724 0.007 0.726 0.010 0.792 0.006 0.447 0.014 Download
MACCS fingerprints 0.792 0.011 0.734 0.006 0.763 0.005 0.768 0.006 0.835 0.005 0.525 0.008 Download
Daylight fingerprints 0.760 0.007 0.830 0.007 0.795 0.005 0.786 0.005 0.861 0.003 0.590 0.009 Download
ECFP2 fingerprints 0.826 0.007 0.798 0.009 0.812 0.006 0.814 0.005 0.908 0.004 0.625 0.012 Download
ECFP4 fingerprints 0.777 0.012 0.891 0.008 0.834 0.007 0.824 0.007 0.919 0.003 0.675 0.014 Download
ECFP6 fingerprints 0.733 0.008 0.945 0.008 0.839 0.010 0.821 0.011 0.914 0.005 0.696 0.015 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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