After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
| Uniprot primary ID | P36544 |
| PDB ID | 2MAW 5AFH 5AFJ 5AFK 5AFL 5AFM 5AFN |
| DrugBank ID | DB00898 DB00514 DB01352 DB01353 DB00674 DB00312 DB00184 |
| BioGrid ID | 107561 |
| GuidetoPHARMACOLOGY ID | 468 |
| PharmGKB ID | PA114;PA26483 |
| KEGG ID | hsa:1139 |
| DIP ID | |
| STRING ID | 9606.ENSP00000299847 |
| IntAct ID | P36544 |
| DMDM | 2506127 |
| BRENDA | |
| Reactome | R-HSA-629594 |
| SignaLink | P36544 |
| BioCyc | |
| Entrez Gene (Gene ID) | 89832;1139 |
| BindingDB | P36544 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.837 | 0.005 | 0.839 | 0.005 | 0.838 | 0.004 | 0.838 | 0.004 | 0.930 | 0.000 | 0.678 | 0.004 | Download |
| Estate fingerprints | 0.845 | 0.005 | 0.817 | 0.005 | 0.831 | 0.003 | 0.832 | 0.004 | 0.900 | 0.000 | 0.659 | 0.007 | Download |
| MACCS fingerprints | 0.859 | 0.003 | 0.785 | 0.005 | 0.822 | 0.004 | 0.830 | 0.000 | 0.880 | 0.000 | 0.647 | 0.005 | Download |
| Daylight fingerprints | 0.808 | 0.004 | 0.792 | 0.005 | 0.800 | 0.000 | 0.800 | 0.000 | 0.820 | 0.000 | 0.603 | 0.005 | Download |
| ECFP2 fingerprints | 0.871 | 0.006 | 0.913 | 0.005 | 0.892 | 0.004 | 0.890 | 0.000 | 0.950 | 0.000 | 0.786 | 0.005 | Download |
| ECFP4 fingerprints | 0.869 | 0.006 | 0.971 | 0.000 | 0.920 | 0.000 | 0.918 | 0.004 | 0.970 | 0.000 | 0.848 | 0.004 | Download |
| ECFP6 fingerprints | 0.856 | 0.005 | 0.990 | 0.003 | 0.923 | 0.005 | 0.919 | 0.003 | 0.970 | 0.000 | 0.856 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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