Target name

P36544: Neuronal acetylcholine receptor subunit alpha-7


  Protein function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

  Database links

Uniprot primary ID P36544
PDB ID 2MAW 5AFH 5AFJ 5AFK 5AFL 5AFM 5AFN
DrugBank ID DB00898 DB00514 DB01352 DB01353 DB00674 DB00312 DB00184
BioGrid ID 107561
GuidetoPHARMACOLOGY ID 468
PharmGKB ID PA114;PA26483
KEGG ID hsa:1139
DIP ID
STRING ID 9606.ENSP00000299847
IntAct ID P36544
DMDM 2506127
BRENDA
Reactome R-HSA-629594
SignaLink P36544
BioCyc
Entrez Gene (Gene ID) 89832;1139
BindingDB P36544

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.837 0.005 0.839 0.005 0.838 0.004 0.838 0.004 0.930 0.000 0.678 0.004 Download
Estate fingerprints 0.845 0.005 0.817 0.005 0.831 0.003 0.832 0.004 0.900 0.000 0.659 0.007 Download
MACCS fingerprints 0.859 0.003 0.785 0.005 0.822 0.004 0.830 0.000 0.880 0.000 0.647 0.005 Download
Daylight fingerprints 0.808 0.004 0.792 0.005 0.800 0.000 0.800 0.000 0.820 0.000 0.603 0.005 Download
ECFP2 fingerprints 0.871 0.006 0.913 0.005 0.892 0.004 0.890 0.000 0.950 0.000 0.786 0.005 Download
ECFP4 fingerprints 0.869 0.006 0.971 0.000 0.920 0.000 0.918 0.004 0.970 0.000 0.848 0.004 Download
ECFP6 fingerprints 0.856 0.005 0.990 0.003 0.923 0.005 0.919 0.003 0.970 0.000 0.856 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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