Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH.
| Uniprot primary ID | P37059 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | 109527 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA29479 |
| KEGG ID | hsa:3294 |
| DIP ID | |
| STRING ID | 9606.ENSP00000199936 |
| IntAct ID | |
| DMDM | 544152 |
| BRENDA | 1.1.1.62 |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 3294 |
| BindingDB | P37059 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.942 | 0.006 | 0.962 | 0.005 | 0.952 | 0.004 | 0.951 | 0.003 | 0.990 | 0.000 | 0.909 | 0.006 | Download |
| Estate fingerprints | 0.920 | 0.005 | 0.914 | 0.004 | 0.917 | 0.005 | 0.917 | 0.005 | 0.970 | 0.000 | 0.830 | 0.007 | Download |
| MACCS fingerprints | 0.973 | 0.005 | 0.937 | 0.004 | 0.955 | 0.005 | 0.955 | 0.005 | 0.980 | 0.000 | 0.910 | 0.005 | Download |
| Daylight fingerprints | 0.893 | 0.005 | 0.867 | 0.000 | 0.880 | 0.000 | 0.883 | 0.005 | 0.920 | 0.000 | 0.766 | 0.005 | Download |
| ECFP2 fingerprints | 0.970 | 0.000 | 0.970 | 0.003 | 0.970 | 0.000 | 0.970 | 0.000 | 0.990 | 0.000 | 0.935 | 0.005 | Download |
| ECFP4 fingerprints | 0.980 | 0.000 | 0.976 | 0.000 | 0.978 | 0.004 | 0.978 | 0.004 | 0.990 | 0.000 | 0.953 | 0.005 | Download |
| ECFP6 fingerprints | 0.970 | 0.000 | 0.990 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 0.990 | 0.000 | 0.957 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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