Target name

P37059: Estradiol 17-beta-dehydrogenase 2


  Protein function

Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH.

  Database links

Uniprot primary ID P37059
PDB ID
DrugBank ID
BioGrid ID 109527
GuidetoPHARMACOLOGY ID
PharmGKB ID PA29479
KEGG ID hsa:3294
DIP ID
STRING ID 9606.ENSP00000199936
IntAct ID
DMDM 544152
BRENDA 1.1.1.62
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 3294
BindingDB P37059

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.942 0.006 0.962 0.005 0.952 0.004 0.951 0.003 0.990 0.000 0.909 0.006 Download
Estate fingerprints 0.920 0.005 0.914 0.004 0.917 0.005 0.917 0.005 0.970 0.000 0.830 0.007 Download
MACCS fingerprints 0.973 0.005 0.937 0.004 0.955 0.005 0.955 0.005 0.980 0.000 0.910 0.005 Download
Daylight fingerprints 0.893 0.005 0.867 0.000 0.880 0.000 0.883 0.005 0.920 0.000 0.766 0.005 Download
ECFP2 fingerprints 0.970 0.000 0.970 0.003 0.970 0.000 0.970 0.000 0.990 0.000 0.935 0.005 Download
ECFP4 fingerprints 0.980 0.000 0.976 0.000 0.978 0.004 0.978 0.004 0.990 0.000 0.953 0.005 Download
ECFP6 fingerprints 0.970 0.000 0.990 0.000 0.980 0.000 0.980 0.000 0.990 0.000 0.957 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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