Target name

P37231: Peroxisome proliferator-activated receptor gamma


  Protein function

Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).

  Database links

Uniprot primary ID P37231
PDB ID 3HO0 4O8F 2HFP 1RDT 1ZGY 1K74 3R8A 3WJ4 3WJ5 1KNU 3PRG 3X1H 2VSR 2Q61 3VN2 3IA6 3AN4 3X1I 3AN3 4L98 3G9E 2VST 4HEE 4F9M 3T03 3V9V 2I4P 3ET0 2I4J 3R5N 3ET3 2OM9 4XLD 3LMP 2PRG 3V9Y 3H0A 4CI5 3QT0 4EMA 3V9T 2I4Z 4PRG 3S9S 1I7I 1ZEO 3KMG 3HOD 3B0R 3B0Q 4OJ4
DrugBank ID DB01050 DB00159 DB01067 DB00328 DB00795 DB00731 DB00966
BioGrid ID 111464
GuidetoPHARMACOLOGY ID 595
PharmGKB ID PA281
KEGG ID hsa:5468
DIP ID DIP-35528N
STRING ID 9606.ENSP00000287820
IntAct ID P37231
DMDM 13432234
BRENDA
Reactome R-HSA-1989781 R-HSA-383280 R-HSA-381340
SignaLink P37231
BioCyc
Entrez Gene (Gene ID) 5468
BindingDB P37231

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.850 0.000 0.910 0.005 0.880 0.000 0.873 0.005 0.940 0.000 0.758 0.004 Download
Estate fingerprints 0.850 0.000 0.830 0.000 0.840 0.000 0.840 0.000 0.920 0.000 0.680 0.000 Download
MACCS fingerprints 0.860 0.000 0.856 0.000 0.858 0.004 0.860 0.000 0.910 0.000 0.710 0.000 Download
Daylight fingerprints 0.771 0.003 0.927 0.004 0.849 0.003 0.833 0.005 0.920 0.000 0.701 0.003 Download
ECFP2 fingerprints 0.926 0.005 0.934 0.004 0.930 0.000 0.930 0.000 0.980 0.000 0.860 0.000 Download
ECFP4 fingerprints 0.900 0.000 0.960 0.003 0.930 0.000 0.930 0.000 0.990 0.000 0.869 0.003 Download
ECFP6 fingerprints 0.870 0.000 0.970 0.000 0.920 0.000 0.920 0.000 0.980 0.000 0.850 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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