Details-Calcnet-TargetNet

Target name

P37268: Squalene synthase

Protein function

endoplasmic reticulum, endoplasmic reticulum membrane, integral component of membrane, farnesyl-diphosphate farnesyltransferase activity, cellular lipid metabolic process, cholesterol biosynthetic process, small molecule metabolic process, steroid biosynthetic process

Database links

Uniprot primary ID	P37268
PDB ID	3VJ9 3VJ8 1EZF 3Q2Z 3WCM 3WCL 3WCJ 3WCI 3WCH 3WCF 3WCD 3WEI 3WEH 3WEK 3WEJ 3WC9 3ASX 3WEG 3WEF 3V66 3WSA 3LEE 3VJA 3VJC 3VJB 3Q30
DrugBank ID
BioGrid ID	108516
GuidetoPHARMACOLOGY ID	645
PharmGKB ID	PA28073
KEGG ID	hsa:2222
DIP ID
STRING ID	9606.ENSP00000220584
IntAct ID	P37268
DMDM	585126
BRENDA	2.5.1.21
Reactome	R-HSA-1989781 R-HSA-191273 R-HSA-2426168
SignaLink
BioCyc	MetaCyc:HS01329-MONOMER
Entrez Gene (Gene ID)	2222
BindingDB	P37268

Model Performance Metrics

Fingerprint type	Sensitivity	SEN_std	Specificity	SPE_std	Accuracy	ACC_std	F1-score	F1-score_std	AUC	AUC_std	MCC	MCC_std	Download model
FP2 fingerprints	0.911	0.003	0.939	0.005	0.925	0.005	0.925	0.005	0.979	0.003	0.854	0.008	Download
Estate fingerprints	0.920	0.005	0.806	0.009	0.863	0.005	0.872	0.004	0.950	0.000	0.730	0.011	Download
MACCS fingerprints	0.917	0.005	0.855	0.007	0.886	0.005	0.889	0.003	0.960	0.000	0.773	0.007	Download
Daylight fingerprints	0.733	0.005	0.999	0.000	0.866	0.005	0.843	0.005	0.971	0.006	0.757	0.007	Download
ECFP2 fingerprints	0.926	0.005	0.966	0.008	0.946	0.005	0.946	0.005	0.990	0.000	0.890	0.007	Download
ECFP4 fingerprints	0.910	0.000	0.994	0.005	0.952	0.004	0.950	0.000	0.990	0.000	0.909	0.007	Download
ECFP6 fingerprints	0.887	0.008	1.000	0.000	0.945	0.005	0.939	0.006	0.990	0.000	0.893	0.008	Download

Download datasets

Positive dataset

Negative dataset