TargetNet
  Target name

P37268: Squalene synthase

  Protein function

endoplasmic reticulum, endoplasmic reticulum membrane, integral component of membrane, farnesyl-diphosphate farnesyltransferase activity, cellular lipid metabolic process, cholesterol biosynthetic process, small molecule metabolic process, steroid biosynthetic process

  Database links
Uniprot primary ID P37268
PDB ID 3VJ9 3VJ8 1EZF 3Q2Z 3WCM 3WCL 3WCJ 3WCI 3WCH 3WCF 3WCD 3WEI 3WEH 3WEK 3WEJ 3WC9 3ASX 3WEG 3WEF 3V66 3WSA 3LEE 3VJA 3VJC 3VJB 3Q30
DrugBank ID
BioGrid ID 108516
GuidetoPHARMACOLOGY ID 645
PharmGKB ID PA28073
KEGG ID hsa:2222
DIP ID
STRING ID 9606.ENSP00000220584
IntAct ID P37268
DMDM 585126
BRENDA 2.5.1.21
Reactome R-HSA-1989781 R-HSA-191273 R-HSA-2426168
SignaLink
BioCyc MetaCyc:HS01329-MONOMER
Entrez Gene (Gene ID) 2222
BindingDB P37268
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.911 0.003 0.939 0.005 0.925 0.005 0.925 0.005 0.979 0.003 0.854 0.008 Download
Estate fingerprints 0.920 0.005 0.806 0.009 0.863 0.005 0.872 0.004 0.950 0.000 0.730 0.011 Download
MACCS fingerprints 0.917 0.005 0.855 0.007 0.886 0.005 0.889 0.003 0.960 0.000 0.773 0.007 Download
Daylight fingerprints 0.733 0.005 0.999 0.000 0.866 0.005 0.843 0.005 0.971 0.006 0.757 0.007 Download
ECFP2 fingerprints 0.926 0.005 0.966 0.008 0.946 0.005 0.946 0.005 0.990 0.000 0.890 0.007 Download
ECFP4 fingerprints 0.910 0.000 0.994 0.005 0.952 0.004 0.950 0.000 0.990 0.000 0.909 0.007 Download
ECFP6 fingerprints 0.887 0.008 1.000 0.000 0.945 0.005 0.939 0.006 0.990 0.000 0.893 0.008 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn