G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
Uniprot primary ID | P41144 |
PDB ID | |
DrugBank ID | |
BioGrid ID | |
GuidetoPHARMACOLOGY ID | |
PharmGKB ID | |
KEGG ID | |
DIP ID | |
STRING ID | 10141.ENSCPOP00000020555 |
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DMDM | |
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SignaLink | |
BioCyc | |
Entrez Gene (Gene ID) | 100135587 |
BindingDB | P41144 |
Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
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FP2 fingerprints | 0.802 | 0.006 | 0.916 | 0.000 | 0.859 | 0.003 | 0.850 | 0.005 | 0.940 | 0.000 | 0.721 | 0.006 | Download |
Estate fingerprints | 0.892 | 0.004 | 0.830 | 0.004 | 0.861 | 0.003 | 0.868 | 0.004 | 0.930 | 0.000 | 0.726 | 0.005 | Download |
MACCS fingerprints | 0.865 | 0.005 | 0.829 | 0.003 | 0.847 | 0.005 | 0.848 | 0.004 | 0.940 | 0.000 | 0.693 | 0.008 | Download |
Daylight fingerprints | 0.663 | 0.005 | 0.861 | 0.000 | 0.762 | 0.004 | 0.736 | 0.005 | 0.788 | 0.004 | 0.534 | 0.005 | Download |
ECFP2 fingerprints | 0.898 | 0.004 | 0.942 | 0.005 | 0.920 | 0.000 | 0.919 | 0.003 | 0.970 | 0.000 | 0.838 | 0.004 | Download |
ECFP4 fingerprints | 0.880 | 0.000 | 0.980 | 0.005 | 0.930 | 0.000 | 0.924 | 0.005 | 0.979 | 0.003 | 0.859 | 0.003 | Download |
ECFP6 fingerprints | 0.850 | 0.000 | 0.986 | 0.000 | 0.918 | 0.004 | 0.910 | 0.000 | 0.972 | 0.004 | 0.840 | 0.000 | Download |
Positive dataset | Negative dataset |
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