Target name

P41144: Kappa-type opioid receptor


  Protein function

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

  Database links

Uniprot primary ID P41144
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID
DIP ID
STRING ID 10141.ENSCPOP00000020555
IntAct ID
DMDM
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 100135587
BindingDB P41144

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.802 0.006 0.916 0.000 0.859 0.003 0.850 0.005 0.940 0.000 0.721 0.006 Download
Estate fingerprints 0.892 0.004 0.830 0.004 0.861 0.003 0.868 0.004 0.930 0.000 0.726 0.005 Download
MACCS fingerprints 0.865 0.005 0.829 0.003 0.847 0.005 0.848 0.004 0.940 0.000 0.693 0.008 Download
Daylight fingerprints 0.663 0.005 0.861 0.000 0.762 0.004 0.736 0.005 0.788 0.004 0.534 0.005 Download
ECFP2 fingerprints 0.898 0.004 0.942 0.005 0.920 0.000 0.919 0.003 0.970 0.000 0.838 0.004 Download
ECFP4 fingerprints 0.880 0.000 0.980 0.005 0.930 0.000 0.924 0.005 0.979 0.003 0.859 0.003 Download
ECFP6 fingerprints 0.850 0.000 0.986 0.000 0.918 0.004 0.910 0.000 0.972 0.004 0.840 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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