G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
Uniprot primary ID | P41145 |
PDB ID | 4DJH 2IQN 2A0D |
DrugBank ID | DB06148 DB00899 DB00652 DB00611 DB00327 DB00321 DB00813 |
BioGrid ID | 111031 |
GuidetoPHARMACOLOGY ID | 318 |
PharmGKB ID | PA31943 |
KEGG ID | hsa:4986 |
DIP ID | |
STRING ID | 9606.ENSP00000265572 |
IntAct ID | P41145 |
DMDM | 116242691 |
BRENDA | |
Reactome | R-HSA-418594 R-HSA-375276 |
SignaLink | P41145 |
BioCyc | |
Entrez Gene (Gene ID) | 4986 |
BindingDB | P41145 |
Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FP2 fingerprints | 0.810 | 0.000 | 0.780 | 0.000 | 0.795 | 0.005 | 0.800 | 0.000 | 0.860 | 0.000 | 0.590 | 0.000 | Download |
Estate fingerprints | 0.810 | 0.000 | 0.750 | 0.005 | 0.780 | 0.000 | 0.787 | 0.005 | 0.843 | 0.005 | 0.560 | 0.000 | Download |
MACCS fingerprints | 0.810 | 0.000 | 0.730 | 0.000 | 0.770 | 0.000 | 0.780 | 0.000 | 0.850 | 0.000 | 0.541 | 0.003 | Download |
Daylight fingerprints | 0.676 | 0.005 | 0.844 | 0.000 | 0.760 | 0.000 | 0.738 | 0.004 | 0.820 | 0.000 | 0.520 | 0.000 | Download |
ECFP2 fingerprints | 0.823 | 0.005 | 0.915 | 0.000 | 0.869 | 0.003 | 0.860 | 0.000 | 0.930 | 0.000 | 0.732 | 0.004 | Download |
ECFP4 fingerprints | 0.820 | 0.000 | 0.960 | 0.000 | 0.890 | 0.000 | 0.880 | 0.000 | 0.950 | 0.000 | 0.790 | 0.000 | Download |
ECFP6 fingerprints | 0.800 | 0.000 | 0.960 | 0.005 | 0.880 | 0.000 | 0.870 | 0.000 | 0.940 | 0.000 | 0.775 | 0.005 | Download |
Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn