Target name

P41145: Kappa-type opioid receptor


  Protein function

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

  Database links

Uniprot primary ID P41145
PDB ID 4DJH 2IQN 2A0D
DrugBank ID DB06148 DB00899 DB00652 DB00611 DB00327 DB00321 DB00813
BioGrid ID 111031
GuidetoPHARMACOLOGY ID 318
PharmGKB ID PA31943
KEGG ID hsa:4986
DIP ID
STRING ID 9606.ENSP00000265572
IntAct ID P41145
DMDM 116242691
BRENDA
Reactome R-HSA-418594 R-HSA-375276
SignaLink P41145
BioCyc
Entrez Gene (Gene ID) 4986
BindingDB P41145

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.810 0.000 0.780 0.000 0.795 0.005 0.800 0.000 0.860 0.000 0.590 0.000 Download
Estate fingerprints 0.810 0.000 0.750 0.005 0.780 0.000 0.787 0.005 0.843 0.005 0.560 0.000 Download
MACCS fingerprints 0.810 0.000 0.730 0.000 0.770 0.000 0.780 0.000 0.850 0.000 0.541 0.003 Download
Daylight fingerprints 0.676 0.005 0.844 0.000 0.760 0.000 0.738 0.004 0.820 0.000 0.520 0.000 Download
ECFP2 fingerprints 0.823 0.005 0.915 0.000 0.869 0.003 0.860 0.000 0.930 0.000 0.732 0.004 Download
ECFP4 fingerprints 0.820 0.000 0.960 0.000 0.890 0.000 0.880 0.000 0.950 0.000 0.790 0.000 Download
ECFP6 fingerprints 0.800 0.000 0.960 0.005 0.880 0.000 0.870 0.000 0.940 0.000 0.775 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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