Target name

P41146: Nociceptin receptor


  Protein function

G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.

  Database links

Uniprot primary ID P41146
PDB ID 4EA3
DrugBank ID
BioGrid ID 111032
GuidetoPHARMACOLOGY ID 320
PharmGKB ID PA31944
KEGG ID hsa:4987
DIP ID
STRING ID 9606.ENSP00000336764
IntAct ID P41146
DMDM 730230
BRENDA
Reactome R-HSA-418594 R-HSA-375276
SignaLink
BioCyc
Entrez Gene (Gene ID) 4987
BindingDB P41146

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.846 0.005 0.814 0.005 0.830 0.000 0.832 0.004 0.910 0.000 0.660 0.005 Download
Estate fingerprints 0.816 0.005 0.750 0.000 0.783 0.005 0.790 0.000 0.860 0.000 0.568 0.004 Download
MACCS fingerprints 0.850 0.000 0.730 0.005 0.790 0.000 0.800 0.000 0.888 0.004 0.582 0.004 Download
Daylight fingerprints 0.719 0.003 0.881 0.000 0.800 0.000 0.780 0.000 0.890 0.000 0.608 0.004 Download
ECFP2 fingerprints 0.900 0.000 0.916 0.003 0.908 0.004 0.906 0.005 0.960 0.000 0.812 0.004 Download
ECFP4 fingerprints 0.943 0.005 0.961 0.003 0.952 0.004 0.952 0.004 0.990 0.000 0.907 0.005 Download
ECFP6 fingerprints 0.925 0.005 0.977 0.004 0.951 0.003 0.950 0.000 0.990 0.000 0.905 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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