Target name

P41180: Extracellular calcium-sensing receptor


  Protein function

Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.

  Database links

Uniprot primary ID P41180
PDB ID
DrugBank ID DB01012
BioGrid ID 107296
GuidetoPHARMACOLOGY ID 54
PharmGKB ID PA26097
KEGG ID hsa:846
DIP ID DIP-5975N
STRING ID 9606.ENSP00000420194
IntAct ID P41180
DMDM 1168781
BRENDA
Reactome R-HSA-418594 R-HSA-420499 R-HSA-416476
SignaLink
BioCyc
Entrez Gene (Gene ID) 846
BindingDB P41180

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.921 0.007 0.915 0.003 0.918 0.004 0.918 0.004 0.979 0.003 0.833 0.007 Download
Estate fingerprints 0.770 0.005 0.810 0.003 0.790 0.000 0.786 0.005 0.890 0.000 0.579 0.006 Download
MACCS fingerprints 0.814 0.007 0.784 0.000 0.799 0.003 0.803 0.005 0.890 0.000 0.601 0.007 Download
Daylight fingerprints 0.901 0.007 0.887 0.007 0.894 0.005 0.894 0.005 0.949 0.003 0.790 0.009 Download
ECFP2 fingerprints 0.962 0.004 0.958 0.000 0.960 0.000 0.960 0.000 0.990 0.000 0.921 0.003 Download
ECFP4 fingerprints 0.988 0.004 0.992 0.000 0.990 0.000 0.990 0.000 1.000 0.000 0.974 0.005 Download
ECFP6 fingerprints 0.961 0.003 1.000 0.000 0.981 0.003 0.981 0.003 1.000 0.000 0.961 0.003 Download

  Download datasets

Positive dataset Negative dataset


The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn