Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.
| Uniprot primary ID | P41231 |
| PDB ID | 1Z8E |
| DrugBank ID | DB04786 |
| BioGrid ID | 111068 |
| GuidetoPHARMACOLOGY ID | 324 |
| PharmGKB ID | PA32870 |
| KEGG ID | hsa:5029 |
| DIP ID | |
| STRING ID | 9606.ENSP00000310305 |
| IntAct ID | P41231 |
| DMDM | 311033490 |
| BRENDA | |
| Reactome | R-HSA-416476 R-HSA-417957 |
| SignaLink | P41231 |
| BioCyc | |
| Entrez Gene (Gene ID) | 5029 |
| BindingDB | P41231 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.900 | 0.000 | 1.000 | 0.000 | 0.950 | 0.000 | 0.950 | 0.000 | 0.993 | 0.005 | 0.910 | 0.000 | Download |
| Estate fingerprints | 0.900 | 0.000 | 1.000 | 0.000 | 0.950 | 0.000 | 0.940 | 0.000 | 0.939 | 0.003 | 0.900 | 0.000 | Download |
| MACCS fingerprints | 0.901 | 0.003 | 0.999 | 0.000 | 0.950 | 0.000 | 0.941 | 0.003 | 0.990 | 0.000 | 0.900 | 0.000 | Download |
| Daylight fingerprints | 0.900 | 0.000 | 1.000 | 0.000 | 0.950 | 0.000 | 0.950 | 0.000 | 0.990 | 0.000 | 0.910 | 0.000 | Download |
| ECFP2 fingerprints | 0.900 | 0.000 | 1.000 | 0.000 | 0.950 | 0.000 | 0.950 | 0.000 | 1.000 | 0.000 | 0.910 | 0.000 | Download |
| ECFP4 fingerprints | 0.900 | 0.000 | 1.000 | 0.000 | 0.950 | 0.000 | 0.950 | 0.000 | 1.000 | 0.000 | 0.910 | 0.000 | Download |
| ECFP6 fingerprints | 0.900 | 0.000 | 1.000 | 0.000 | 0.950 | 0.000 | 0.950 | 0.000 | 1.000 | 0.000 | 0.910 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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