Target name

P41231: P2Y purinoceptor 2


  Protein function

Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.

  Database links

Uniprot primary ID P41231
PDB ID 1Z8E
DrugBank ID DB04786
BioGrid ID 111068
GuidetoPHARMACOLOGY ID 324
PharmGKB ID PA32870
KEGG ID hsa:5029
DIP ID
STRING ID 9606.ENSP00000310305
IntAct ID P41231
DMDM 311033490
BRENDA
Reactome R-HSA-416476 R-HSA-417957
SignaLink P41231
BioCyc
Entrez Gene (Gene ID) 5029
BindingDB P41231

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.900 0.000 1.000 0.000 0.950 0.000 0.950 0.000 0.993 0.005 0.910 0.000 Download
Estate fingerprints 0.900 0.000 1.000 0.000 0.950 0.000 0.940 0.000 0.939 0.003 0.900 0.000 Download
MACCS fingerprints 0.901 0.003 0.999 0.000 0.950 0.000 0.941 0.003 0.990 0.000 0.900 0.000 Download
Daylight fingerprints 0.900 0.000 1.000 0.000 0.950 0.000 0.950 0.000 0.990 0.000 0.910 0.000 Download
ECFP2 fingerprints 0.900 0.000 1.000 0.000 0.950 0.000 0.950 0.000 1.000 0.000 0.910 0.000 Download
ECFP4 fingerprints 0.900 0.000 1.000 0.000 0.950 0.000 0.950 0.000 1.000 0.000 0.910 0.000 Download
ECFP6 fingerprints 0.900 0.000 1.000 0.000 0.950 0.000 0.950 0.000 1.000 0.000 0.910 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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