Target name

P41235: Hepatocyte nuclear factor 4-alpha


  Protein function

Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine.

  Database links

Uniprot primary ID P41235
PDB ID 1PZL 3CBB 4B7W 4IQR 3FS1
DrugBank ID
BioGrid ID 109414
GuidetoPHARMACOLOGY ID 608
PharmGKB ID PA29349
KEGG ID hsa:3172
DIP ID DIP-499N
STRING ID 9606.ENSP00000312987
IntAct ID P41235
DMDM 148886624
BRENDA
Reactome R-HSA-383280 R-HSA-210745
SignaLink P41235
BioCyc
Entrez Gene (Gene ID) 3172
BindingDB P41235

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.671 0.014 0.969 0.005 0.820 0.007 0.787 0.009 0.899 0.003 0.671 0.011 Download
Estate fingerprints 0.799 0.018 0.797 0.006 0.798 0.009 0.798 0.009 0.870 0.000 0.600 0.017 Download
MACCS fingerprints 0.813 0.012 0.815 0.007 0.814 0.008 0.815 0.008 0.873 0.005 0.631 0.014 Download
Daylight fingerprints 0.486 0.007 0.936 0.006 0.711 0.003 0.625 0.005 0.702 0.006 0.472 0.009 Download
ECFP2 fingerprints 0.838 0.014 0.882 0.010 0.860 0.009 0.856 0.010 0.930 0.005 0.718 0.019 Download
ECFP4 fingerprints 0.774 0.011 0.912 0.000 0.843 0.005 0.831 0.007 0.918 0.004 0.692 0.011 Download
ECFP6 fingerprints 0.741 0.009 0.949 0.008 0.845 0.005 0.827 0.007 0.927 0.005 0.704 0.010 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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