Target name

P41279: Mitogen-activated protein kinase kinase kinase 8


  Protein function

Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant.

  Database links

Uniprot primary ID P41279
PDB ID 4Y83 4Y85
DrugBank ID
BioGrid ID 107719
GuidetoPHARMACOLOGY ID 2083
PharmGKB ID PA30606
KEGG ID hsa:1326
DIP ID DIP-27534N
STRING ID 9606.ENSP00000263056
IntAct ID P41279
DMDM 50403742
BRENDA
Reactome R-HSA-450294 R-HSA-389357 R-HSA-446652
SignaLink P41279
BioCyc
Entrez Gene (Gene ID) 1326
BindingDB P41279

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.917 0.007 0.985 0.000 0.951 0.003 0.951 0.003 0.969 0.003 0.911 0.003 Download
Estate fingerprints 0.828 0.010 0.892 0.007 0.860 0.008 0.856 0.008 0.942 0.004 0.724 0.016 Download
MACCS fingerprints 0.869 0.006 0.875 0.005 0.872 0.004 0.871 0.003 0.939 0.003 0.743 0.007 Download
Daylight fingerprints 0.708 0.013 1.000 0.000 0.855 0.007 0.829 0.009 0.960 0.000 0.740 0.012 Download
ECFP2 fingerprints 0.915 0.008 0.983 0.000 0.949 0.003 0.946 0.005 0.980 0.000 0.895 0.007 Download
ECFP4 fingerprints 0.913 0.005 0.999 0.000 0.956 0.005 0.956 0.005 0.980 0.000 0.916 0.005 Download
ECFP6 fingerprints 0.900 0.008 0.996 0.000 0.948 0.004 0.947 0.005 0.980 0.000 0.904 0.008 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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