Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection.
| Uniprot primary ID | P41597 |
| PDB ID | 1KAD 1KP1 |
| DrugBank ID | |
| BioGrid ID | 609634 |
| GuidetoPHARMACOLOGY ID | 59 |
| PharmGKB ID | PA26167 |
| KEGG ID | hsa:729230 |
| DIP ID | DIP-5833N;DIP-5839N |
| STRING ID | 9606.ENSP00000292301 |
| IntAct ID | |
| DMDM | 1168965 |
| BRENDA | |
| Reactome | R-HSA-418594 R-HSA-1461957 R-HSA-380108 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 729230 |
| BindingDB | P41597 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.851 | 0.003 | 0.849 | 0.000 | 0.850 | 0.000 | 0.850 | 0.000 | 0.940 | 0.000 | 0.700 | 0.000 | Download |
| Estate fingerprints | 0.833 | 0.005 | 0.787 | 0.000 | 0.810 | 0.000 | 0.820 | 0.000 | 0.890 | 0.000 | 0.625 | 0.005 | Download |
| MACCS fingerprints | 0.860 | 0.000 | 0.820 | 0.004 | 0.840 | 0.000 | 0.847 | 0.005 | 0.910 | 0.000 | 0.689 | 0.003 | Download |
| Daylight fingerprints | 0.820 | 0.000 | 0.866 | 0.003 | 0.843 | 0.005 | 0.840 | 0.000 | 0.900 | 0.000 | 0.688 | 0.004 | Download |
| ECFP2 fingerprints | 0.867 | 0.005 | 0.953 | 0.000 | 0.910 | 0.000 | 0.910 | 0.000 | 0.980 | 0.000 | 0.830 | 0.000 | Download |
| ECFP4 fingerprints | 0.910 | 0.000 | 0.990 | 0.005 | 0.950 | 0.000 | 0.947 | 0.005 | 0.990 | 0.000 | 0.899 | 0.003 | Download |
| ECFP6 fingerprints | 0.890 | 0.000 | 0.990 | 0.000 | 0.940 | 0.000 | 0.940 | 0.000 | 0.990 | 0.000 | 0.890 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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