Target name

P41597: C-C chemokine receptor type 2


  Protein function

Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection.

  Database links

Uniprot primary ID P41597
PDB ID 1KAD 1KP1
DrugBank ID
BioGrid ID 609634
GuidetoPHARMACOLOGY ID 59
PharmGKB ID PA26167
KEGG ID hsa:729230
DIP ID DIP-5833N;DIP-5839N
STRING ID 9606.ENSP00000292301
IntAct ID
DMDM 1168965
BRENDA
Reactome R-HSA-418594 R-HSA-1461957 R-HSA-380108
SignaLink
BioCyc
Entrez Gene (Gene ID) 729230
BindingDB P41597

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.851 0.003 0.849 0.000 0.850 0.000 0.850 0.000 0.940 0.000 0.700 0.000 Download
Estate fingerprints 0.833 0.005 0.787 0.000 0.810 0.000 0.820 0.000 0.890 0.000 0.625 0.005 Download
MACCS fingerprints 0.860 0.000 0.820 0.004 0.840 0.000 0.847 0.005 0.910 0.000 0.689 0.003 Download
Daylight fingerprints 0.820 0.000 0.866 0.003 0.843 0.005 0.840 0.000 0.900 0.000 0.688 0.004 Download
ECFP2 fingerprints 0.867 0.005 0.953 0.000 0.910 0.000 0.910 0.000 0.980 0.000 0.830 0.000 Download
ECFP4 fingerprints 0.910 0.000 0.990 0.005 0.950 0.000 0.947 0.005 0.990 0.000 0.899 0.003 Download
ECFP6 fingerprints 0.890 0.000 0.990 0.000 0.940 0.000 0.940 0.000 0.990 0.000 0.890 0.000 Download

  Download datasets

Positive dataset Negative dataset


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 E-mail: biomed@csu.edu.cn