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E-mail: biomed@csu.edu.cn
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Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain.
| Uniprot primary ID | P41968 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | 110329 |
| GuidetoPHARMACOLOGY ID | 284 |
| PharmGKB ID | PA30675 |
| KEGG ID | hsa:4159 |
| DIP ID | DIP-48790N |
| STRING ID | 9606.ENSP00000243911 |
| IntAct ID | P41968 |
| DMDM | 395398606 |
| BRENDA | |
| Reactome | R-HSA-418555 R-HSA-375276 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 4159 |
| BindingDB | P41968 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.931 | 0.003 | 0.947 | 0.000 | 0.939 | 0.003 | 0.939 | 0.003 | 0.970 | 0.000 | 0.874 | 0.005 | Download |
| Estate fingerprints | 0.910 | 0.000 | 0.854 | 0.004 | 0.882 | 0.004 | 0.887 | 0.005 | 0.960 | 0.000 | 0.766 | 0.007 | Download |
| MACCS fingerprints | 0.904 | 0.005 | 0.888 | 0.004 | 0.896 | 0.005 | 0.897 | 0.005 | 0.960 | 0.000 | 0.793 | 0.005 | Download |
| Daylight fingerprints | 0.857 | 0.005 | 0.959 | 0.004 | 0.908 | 0.004 | 0.901 | 0.003 | 0.950 | 0.000 | 0.819 | 0.006 | Download |
| ECFP2 fingerprints | 0.919 | 0.003 | 0.961 | 0.000 | 0.940 | 0.000 | 0.940 | 0.000 | 0.980 | 0.000 | 0.881 | 0.003 | Download |
| ECFP4 fingerprints | 0.910 | 0.000 | 0.970 | 0.000 | 0.940 | 0.000 | 0.940 | 0.000 | 0.990 | 0.000 | 0.886 | 0.005 | Download |
| ECFP6 fingerprints | 0.867 | 0.005 | 0.973 | 0.000 | 0.920 | 0.000 | 0.918 | 0.004 | 0.990 | 0.000 | 0.848 | 0.004 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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