Target name

P41968: Melanocortin receptor 3


  Protein function

Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain.

  Database links

Uniprot primary ID P41968
PDB ID
DrugBank ID
BioGrid ID 110329
GuidetoPHARMACOLOGY ID 284
PharmGKB ID PA30675
KEGG ID hsa:4159
DIP ID DIP-48790N
STRING ID 9606.ENSP00000243911
IntAct ID P41968
DMDM 395398606
BRENDA
Reactome R-HSA-418555 R-HSA-375276
SignaLink
BioCyc
Entrez Gene (Gene ID) 4159
BindingDB P41968

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.931 0.003 0.947 0.000 0.939 0.003 0.939 0.003 0.970 0.000 0.874 0.005 Download
Estate fingerprints 0.910 0.000 0.854 0.004 0.882 0.004 0.887 0.005 0.960 0.000 0.766 0.007 Download
MACCS fingerprints 0.904 0.005 0.888 0.004 0.896 0.005 0.897 0.005 0.960 0.000 0.793 0.005 Download
Daylight fingerprints 0.857 0.005 0.959 0.004 0.908 0.004 0.901 0.003 0.950 0.000 0.819 0.006 Download
ECFP2 fingerprints 0.919 0.003 0.961 0.000 0.940 0.000 0.940 0.000 0.980 0.000 0.881 0.003 Download
ECFP4 fingerprints 0.910 0.000 0.970 0.000 0.940 0.000 0.940 0.000 0.990 0.000 0.886 0.005 Download
ECFP6 fingerprints 0.867 0.005 0.973 0.000 0.920 0.000 0.918 0.004 0.990 0.000 0.848 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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