Target name

P42262: Glutamate receptor 2


  Protein function

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

  Database links

Uniprot primary ID P42262
PDB ID 2XHD 2WJX 2WJW 3RNN 3RN8 3UA8 3R7X
DrugBank ID DB00898 DB01346 DB01352 DB01353 DB01174 DB00312 DB01351
BioGrid ID 109148
GuidetoPHARMACOLOGY ID 445
PharmGKB ID PA28967
KEGG ID hsa:2891
DIP ID DIP-42852N
STRING ID 9606.ENSP00000264426
IntAct ID P42262
DMDM 23831146
BRENDA
Reactome R-HSA-416993 R-HSA-399710 R-HSA-438066
SignaLink P42262
BioCyc
Entrez Gene (Gene ID) 2891
BindingDB P42262

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.906 0.008 0.978 0.007 0.942 0.004 0.940 0.007 0.988 0.004 0.886 0.011 Download
Estate fingerprints 0.927 0.007 0.869 0.008 0.898 0.006 0.900 0.005 0.960 0.000 0.801 0.012 Download
MACCS fingerprints 0.765 0.016 0.903 0.004 0.834 0.007 0.822 0.009 0.932 0.004 0.676 0.010 Download
Daylight fingerprints 0.765 0.018 0.991 0.006 0.878 0.008 0.862 0.011 0.969 0.003 0.777 0.019 Download
ECFP2 fingerprints 0.965 0.008 0.969 0.009 0.967 0.007 0.967 0.007 0.996 0.007 0.936 0.008 Download
ECFP4 fingerprints 0.984 0.015 0.964 0.008 0.974 0.007 0.974 0.007 0.999 0.003 0.945 0.007 Download
ECFP6 fingerprints 0.980 0.008 0.978 0.010 0.979 0.007 0.979 0.007 1.000 0.000 0.956 0.013 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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