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E-mail: biomed@csu.edu.cn
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Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
| Uniprot primary ID | P42262 |
| PDB ID | 2XHD 2WJX 2WJW 3RNN 3RN8 3UA8 3R7X |
| DrugBank ID | DB00898 DB01346 DB01352 DB01353 DB01174 DB00312 DB01351 |
| BioGrid ID | 109148 |
| GuidetoPHARMACOLOGY ID | 445 |
| PharmGKB ID | PA28967 |
| KEGG ID | hsa:2891 |
| DIP ID | DIP-42852N |
| STRING ID | 9606.ENSP00000264426 |
| IntAct ID | P42262 |
| DMDM | 23831146 |
| BRENDA | |
| Reactome | R-HSA-416993 R-HSA-399710 R-HSA-438066 |
| SignaLink | P42262 |
| BioCyc | |
| Entrez Gene (Gene ID) | 2891 |
| BindingDB | P42262 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.906 | 0.008 | 0.978 | 0.007 | 0.942 | 0.004 | 0.940 | 0.007 | 0.988 | 0.004 | 0.886 | 0.011 | Download |
| Estate fingerprints | 0.927 | 0.007 | 0.869 | 0.008 | 0.898 | 0.006 | 0.900 | 0.005 | 0.960 | 0.000 | 0.801 | 0.012 | Download |
| MACCS fingerprints | 0.765 | 0.016 | 0.903 | 0.004 | 0.834 | 0.007 | 0.822 | 0.009 | 0.932 | 0.004 | 0.676 | 0.010 | Download |
| Daylight fingerprints | 0.765 | 0.018 | 0.991 | 0.006 | 0.878 | 0.008 | 0.862 | 0.011 | 0.969 | 0.003 | 0.777 | 0.019 | Download |
| ECFP2 fingerprints | 0.965 | 0.008 | 0.969 | 0.009 | 0.967 | 0.007 | 0.967 | 0.007 | 0.996 | 0.007 | 0.936 | 0.008 | Download |
| ECFP4 fingerprints | 0.984 | 0.015 | 0.964 | 0.008 | 0.974 | 0.007 | 0.974 | 0.007 | 0.999 | 0.003 | 0.945 | 0.007 | Download |
| ECFP6 fingerprints | 0.980 | 0.008 | 0.978 | 0.010 | 0.979 | 0.007 | 0.979 | 0.007 | 1.000 | 0.000 | 0.956 | 0.013 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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