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E-mail: biomed@csu.edu.cn
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Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
| Uniprot primary ID | P42330 |
| PDB ID | 1XF0 1S1R 1S1P 3R43 4DBS 4DBW 4XVD 4DBU 4HMN 4FA3 2FGB 3R8H 1ZQ5 3R6I 4WDX 2F38 3R94 4WDW 4WDU 3UGR 3R58 4DZ5 3R7M 1S2C 1S2A 3UG8 3UWE 4XVE 3UFY 4FAM 4FAL 4H7C 3R8G 1RY8 1RY0 4WDT 4WRH |
| DrugBank ID | DB00997 DB00905 |
| BioGrid ID | 114196 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA24679 |
| KEGG ID | hsa:8644 |
| DIP ID | |
| STRING ID | 9606.ENSP00000369927 |
| IntAct ID | P42330 |
| DMDM | 308153646 |
| BRENDA | 1.1.1.239 1.3.1.20 1.1.1.21 1.1.1.64 |
| Reactome | R-HSA-5365859 R-HSA-193807 R-HSA-193368 R-HSA-193775 R-HSA-2162123 R-HSA-975634 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 8644 |
| BindingDB | P42330 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.953 | 0.005 | 0.949 | 0.004 | 0.951 | 0.003 | 0.951 | 0.003 | 0.981 | 0.003 | 0.901 | 0.006 | Download |
| Estate fingerprints | 0.912 | 0.006 | 0.868 | 0.007 | 0.890 | 0.005 | 0.892 | 0.006 | 0.960 | 0.000 | 0.780 | 0.009 | Download |
| MACCS fingerprints | 0.954 | 0.005 | 0.876 | 0.005 | 0.915 | 0.005 | 0.921 | 0.003 | 0.960 | 0.000 | 0.835 | 0.007 | Download |
| Daylight fingerprints | 0.753 | 0.005 | 0.827 | 0.005 | 0.790 | 0.000 | 0.780 | 0.000 | 0.880 | 0.000 | 0.581 | 0.003 | Download |
| ECFP2 fingerprints | 0.970 | 0.000 | 0.930 | 0.000 | 0.950 | 0.000 | 0.950 | 0.000 | 0.990 | 0.000 | 0.900 | 0.000 | Download |
| ECFP4 fingerprints | 0.963 | 0.005 | 0.947 | 0.007 | 0.955 | 0.005 | 0.955 | 0.005 | 0.990 | 0.000 | 0.908 | 0.004 | Download |
| ECFP6 fingerprints | 0.957 | 0.005 | 0.963 | 0.005 | 0.960 | 0.000 | 0.960 | 0.000 | 0.990 | 0.000 | 0.915 | 0.005 | Download |
| Positive dataset | Negative dataset |
The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
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