Target name

P42338: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

  Protein function

Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors.

  Database links

Uniprot primary ID P42338
DrugBank ID DB00201
BioGrid ID 111309
PharmGKB ID PA33309
STRING ID 9606.ENSP00000289153
IntAct ID P42338
DMDM 1171955
Reactome R-HSA-1660499 R-HSA-2029485 R-HSA-202424 R-HSA-198203 R-HSA-1257604 R-HSA-4420097 R-HSA-114604 R-HSA-912526 R-HSA-2219530 R-HSA-109704 R-HSA-392451 R-HSA-210993 R-HSA-186763 R-HSA-512988 R-HSA-912631 R-HSA-2424491 R-HSA-373753 R-HSA-2730905
SignaLink P42338
BioCyc MetaCyc:HS00644-MONOMER
Entrez Gene (Gene ID) 5291
BindingDB P42338

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.951 0.003 0.899 0.003 0.925 0.005 0.928 0.004 0.970 0.000 0.850 0.005 Download
Estate fingerprints 0.851 0.003 0.769 0.004 0.810 0.000 0.817 0.005 0.896 0.005 0.619 0.006 Download
MACCS fingerprints 0.896 0.005 0.824 0.005 0.860 0.000 0.864 0.005 0.930 0.000 0.720 0.007 Download
Daylight fingerprints 0.910 0.005 0.788 0.000 0.849 0.003 0.858 0.004 0.890 0.000 0.700 0.005 Download
ECFP2 fingerprints 0.970 0.000 0.910 0.003 0.940 0.000 0.940 0.000 0.990 0.000 0.880 0.000 Download
ECFP4 fingerprints 0.960 0.000 0.976 0.000 0.968 0.004 0.968 0.004 0.990 0.000 0.933 0.005 Download
ECFP6 fingerprints 0.946 0.005 0.992 0.000 0.969 0.003 0.968 0.004 0.990 0.000 0.938 0.004 Download

  Download datasets

Positive dataset Negative dataset

Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).