The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
 |
 |
 |
 |
 |
 |
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
| Uniprot primary ID | P42574 |
| PDB ID | 2J31 2J30 2J33 2J32 4EHH 4EHK 4EHL 4EHD 4EHF 4EHA 2XYP 4JQZ 4QUB 4EHN 3PCX 4QUG 4QUD 1CP3 4QUJ 4QUH 4QUI 2XYG 4QUL 1RE1 3PD1 3PD0 3KJF 3DEJ 3DEK 3DEH 3DEI 2DKO 2XZT 2CJY 2CJX 4QTY 3H0E 1PAU 2XZD 4PS0 4JQY 3ITN 2CDR 4DCO 3GJS 4DCJ 4QUE 2C2K 4QUA 4DCP 4PRY |
| DrugBank ID | DB01017 |
| BioGrid ID | 107286 |
| GuidetoPHARMACOLOGY ID | 1619 |
| PharmGKB ID | PA26087 |
| KEGG ID | hsa:836 |
| DIP ID | DIP-268N |
| STRING ID | 9606.ENSP00000311032 |
| IntAct ID | P42574 |
| DMDM | 77416852 |
| BRENDA | 3.4.22.56 |
| Reactome | R-HSA-211227 R-HSA-205025 R-HSA-264870 R-HSA-111465 R-HSA-111464 R-HSA-211736 R-HSA-1474228 R-HSA-2028269 R-HSA-111463 R-HSA-351906 R-HSA-111459 R-HSA-418889 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 836 |
| BindingDB | P42574 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.779 | 0.003 | 0.941 | 0.005 | 0.860 | 0.000 | 0.850 | 0.000 | 0.890 | 0.000 | 0.731 | 0.003 | Download |
| Estate fingerprints | 0.809 | 0.003 | 0.673 | 0.005 | 0.741 | 0.003 | 0.760 | 0.000 | 0.820 | 0.000 | 0.489 | 0.006 | Download |
| MACCS fingerprints | 0.740 | 0.000 | 0.828 | 0.003 | 0.784 | 0.005 | 0.774 | 0.005 | 0.850 | 0.000 | 0.570 | 0.000 | Download |
| Daylight fingerprints | 0.758 | 0.004 | 0.938 | 0.003 | 0.848 | 0.004 | 0.830 | 0.000 | 0.840 | 0.000 | 0.701 | 0.003 | Download |
| ECFP2 fingerprints | 0.832 | 0.004 | 0.948 | 0.004 | 0.890 | 0.000 | 0.884 | 0.005 | 0.960 | 0.000 | 0.786 | 0.005 | Download |
| ECFP4 fingerprints | 0.805 | 0.005 | 0.975 | 0.000 | 0.890 | 0.000 | 0.880 | 0.000 | 0.970 | 0.000 | 0.800 | 0.000 | Download |
| ECFP6 fingerprints | 0.780 | 0.000 | 1.000 | 0.000 | 0.890 | 0.000 | 0.874 | 0.005 | 0.960 | 0.000 | 0.794 | 0.005 | Download |
| Positive dataset | Negative dataset |
The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
| |
|
|
| |
|
|