Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.
| Uniprot primary ID | P42785 |
| PDB ID | 3N2Z |
| DrugBank ID | |
| BioGrid ID | 111538 |
| GuidetoPHARMACOLOGY ID | 1584 |
| PharmGKB ID | PA33705 |
| KEGG ID | hsa:5547 |
| DIP ID | |
| STRING ID | 9606.ENSP00000377055 |
| IntAct ID | P42785 |
| DMDM | 1172047 |
| BRENDA | 3.4.16.2 |
| Reactome | R-HSA-140837 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 5547 |
| BindingDB | P42785 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.908 | 0.006 | 0.970 | 0.005 | 0.939 | 0.003 | 0.935 | 0.005 | 0.980 | 0.000 | 0.874 | 0.007 | Download |
| Estate fingerprints | 0.853 | 0.005 | 0.877 | 0.000 | 0.865 | 0.005 | 0.864 | 0.005 | 0.940 | 0.000 | 0.730 | 0.009 | Download |
| MACCS fingerprints | 0.838 | 0.006 | 0.820 | 0.004 | 0.829 | 0.003 | 0.829 | 0.003 | 0.920 | 0.000 | 0.663 | 0.007 | Download |
| Daylight fingerprints | 0.840 | 0.000 | 0.982 | 0.000 | 0.911 | 0.003 | 0.910 | 0.000 | 0.949 | 0.003 | 0.840 | 0.000 | Download |
| ECFP2 fingerprints | 0.933 | 0.009 | 0.969 | 0.000 | 0.951 | 0.006 | 0.951 | 0.006 | 0.990 | 0.000 | 0.902 | 0.010 | Download |
| ECFP4 fingerprints | 0.934 | 0.005 | 0.994 | 0.000 | 0.964 | 0.005 | 0.964 | 0.005 | 1.000 | 0.000 | 0.931 | 0.003 | Download |
| ECFP6 fingerprints | 0.914 | 0.005 | 1.000 | 0.000 | 0.959 | 0.003 | 0.954 | 0.005 | 0.999 | 0.003 | 0.919 | 0.003 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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