Target name

P42785: Lysosomal Pro-X carboxypeptidase


  Protein function

Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.

  Database links

Uniprot primary ID P42785
PDB ID 3N2Z
DrugBank ID
BioGrid ID 111538
GuidetoPHARMACOLOGY ID 1584
PharmGKB ID PA33705
KEGG ID hsa:5547
DIP ID
STRING ID 9606.ENSP00000377055
IntAct ID P42785
DMDM 1172047
BRENDA 3.4.16.2
Reactome R-HSA-140837
SignaLink
BioCyc
Entrez Gene (Gene ID) 5547
BindingDB P42785

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.908 0.006 0.970 0.005 0.939 0.003 0.935 0.005 0.980 0.000 0.874 0.007 Download
Estate fingerprints 0.853 0.005 0.877 0.000 0.865 0.005 0.864 0.005 0.940 0.000 0.730 0.009 Download
MACCS fingerprints 0.838 0.006 0.820 0.004 0.829 0.003 0.829 0.003 0.920 0.000 0.663 0.007 Download
Daylight fingerprints 0.840 0.000 0.982 0.000 0.911 0.003 0.910 0.000 0.949 0.003 0.840 0.000 Download
ECFP2 fingerprints 0.933 0.009 0.969 0.000 0.951 0.006 0.951 0.006 0.990 0.000 0.902 0.010 Download
ECFP4 fingerprints 0.934 0.005 0.994 0.000 0.964 0.005 0.964 0.005 1.000 0.000 0.931 0.003 Download
ECFP6 fingerprints 0.914 0.005 1.000 0.000 0.959 0.003 0.954 0.005 0.999 0.003 0.919 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn