Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.
| Uniprot primary ID | P43088 |
| PDB ID | |
| DrugBank ID | DB00654 DB00905 DB00287 DB08819 DB01160 |
| BioGrid ID | 111709 |
| GuidetoPHARMACOLOGY ID | 344 |
| PharmGKB ID | PA290 |
| KEGG ID | hsa:5737 |
| DIP ID | |
| STRING ID | 9606.ENSP00000359793 |
| IntAct ID | |
| DMDM | 1172442 |
| BRENDA | |
| Reactome | R-HSA-391908 R-HSA-416476 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 5737 |
| BindingDB | P43088 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.848 | 0.010 | 0.936 | 0.008 | 0.892 | 0.008 | 0.884 | 0.008 | 0.945 | 0.005 | 0.782 | 0.012 | Download |
| Estate fingerprints | 0.856 | 0.013 | 0.834 | 0.007 | 0.845 | 0.012 | 0.847 | 0.011 | 0.908 | 0.004 | 0.690 | 0.017 | Download |
| MACCS fingerprints | 0.888 | 0.010 | 0.918 | 0.005 | 0.903 | 0.005 | 0.902 | 0.006 | 0.950 | 0.000 | 0.812 | 0.012 | Download |
| Daylight fingerprints | 0.588 | 0.004 | 0.852 | 0.005 | 0.720 | 0.000 | 0.679 | 0.003 | 0.750 | 0.009 | 0.463 | 0.007 | Download |
| ECFP2 fingerprints | 0.896 | 0.007 | 0.966 | 0.008 | 0.931 | 0.006 | 0.928 | 0.008 | 0.970 | 0.000 | 0.863 | 0.013 | Download |
| ECFP4 fingerprints | 0.903 | 0.007 | 0.979 | 0.003 | 0.941 | 0.007 | 0.941 | 0.007 | 0.980 | 0.000 | 0.889 | 0.013 | Download |
| ECFP6 fingerprints | 0.904 | 0.011 | 1.000 | 0.000 | 0.954 | 0.007 | 0.949 | 0.006 | 0.979 | 0.003 | 0.911 | 0.013 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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