Target name

P43088: Prostaglandin F2-alpha receptor


  Protein function

Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.

  Database links

Uniprot primary ID P43088
PDB ID
DrugBank ID DB00654 DB00905 DB00287 DB08819 DB01160
BioGrid ID 111709
GuidetoPHARMACOLOGY ID 344
PharmGKB ID PA290
KEGG ID hsa:5737
DIP ID
STRING ID 9606.ENSP00000359793
IntAct ID
DMDM 1172442
BRENDA
Reactome R-HSA-391908 R-HSA-416476
SignaLink
BioCyc
Entrez Gene (Gene ID) 5737
BindingDB P43088

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.848 0.010 0.936 0.008 0.892 0.008 0.884 0.008 0.945 0.005 0.782 0.012 Download
Estate fingerprints 0.856 0.013 0.834 0.007 0.845 0.012 0.847 0.011 0.908 0.004 0.690 0.017 Download
MACCS fingerprints 0.888 0.010 0.918 0.005 0.903 0.005 0.902 0.006 0.950 0.000 0.812 0.012 Download
Daylight fingerprints 0.588 0.004 0.852 0.005 0.720 0.000 0.679 0.003 0.750 0.009 0.463 0.007 Download
ECFP2 fingerprints 0.896 0.007 0.966 0.008 0.931 0.006 0.928 0.008 0.970 0.000 0.863 0.013 Download
ECFP4 fingerprints 0.903 0.007 0.979 0.003 0.941 0.007 0.941 0.007 0.980 0.000 0.889 0.013 Download
ECFP6 fingerprints 0.904 0.011 1.000 0.000 0.954 0.007 0.949 0.006 0.979 0.003 0.911 0.013 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn