Target name

P43115: Prostaglandin E2 receptor EP3 subtype


  Protein function

Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems (By similarity).

  Database links

Uniprot primary ID P43115
PDB ID
DrugBank ID DB00917 DB00905 DB00929
BioGrid ID 111705
GuidetoPHARMACOLOGY ID 342
PharmGKB ID PA288
KEGG ID hsa:5733
DIP ID
STRING ID 9606.ENSP00000349003
IntAct ID
DMDM 1172071
BRENDA
Reactome R-HSA-391908 R-HSA-418594
SignaLink
BioCyc
Entrez Gene (Gene ID) 5733
BindingDB

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.686 0.008 0.984 0.000 0.835 0.005 0.805 0.007 0.950 0.000 0.699 0.006 Download
Estate fingerprints 0.856 0.005 0.866 0.000 0.861 0.003 0.860 0.000 0.940 0.000 0.727 0.005 Download
MACCS fingerprints 0.653 0.005 0.885 0.003 0.769 0.003 0.739 0.003 0.917 0.005 0.547 0.005 Download
Daylight fingerprints 0.698 0.004 0.920 0.005 0.809 0.003 0.784 0.005 0.829 0.003 0.631 0.006 Download
ECFP2 fingerprints 0.867 0.005 0.973 0.000 0.920 0.000 0.918 0.004 0.990 0.000 0.848 0.004 Download
ECFP4 fingerprints 0.863 0.005 0.997 0.005 0.930 0.000 0.926 0.005 0.990 0.000 0.868 0.004 Download
ECFP6 fingerprints 0.840 0.000 1.000 0.000 0.920 0.000 0.913 0.005 0.990 0.000 0.850 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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