TargetNet
  Target name

P43116: Prostaglandin E2 receptor EP2 subtype

  Protein function

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

  Database links
Uniprot primary ID P43116
PDB ID
DrugBank ID DB00917 DB00770 DB00929
BioGrid ID
GuidetoPHARMACOLOGY ID 341
PharmGKB ID PA287
KEGG ID hsa:5732
DIP ID
STRING ID 9606.ENSP00000245457
IntAct ID P43116
DMDM 38258920
BRENDA
Reactome R-HSA-391908 R-HSA-418555
SignaLink
BioCyc
Entrez Gene (Gene ID) 5732
BindingDB P43116
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.853 0.009 0.905 0.005 0.879 0.006 0.876 0.008 0.938 0.004 0.760 0.012 Download
Estate fingerprints 0.871 0.006 0.797 0.006 0.834 0.007 0.842 0.004 0.923 0.005 0.672 0.011 Download
MACCS fingerprints 0.842 0.006 0.898 0.000 0.870 0.000 0.869 0.003 0.950 0.000 0.742 0.006 Download
Daylight fingerprints 0.735 0.005 0.819 0.003 0.777 0.005 0.767 0.005 0.780 0.000 0.557 0.008 Download
ECFP2 fingerprints 0.961 0.006 0.917 0.006 0.939 0.003 0.941 0.006 0.980 0.000 0.880 0.007 Download
ECFP4 fingerprints 0.949 0.003 0.949 0.003 0.949 0.003 0.949 0.003 0.980 0.000 0.899 0.003 Download
ECFP6 fingerprints 0.894 0.008 0.964 0.000 0.929 0.003 0.927 0.005 0.980 0.000 0.862 0.006 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn