Target name

P43235: Cathepsin K


  Protein function

Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.

  Database links

Uniprot primary ID P43235
PDB ID 1YK8 3O0U 1YK7 1U9W 1U9V 7PCK 4LEG 1U9X 1VSN 1NLJ 4X6J 4X6H 2R6N 1SNK 1TU6 3KW9 2ATO 4N8W 1AU2 3KWZ 4N79 1BY8 1AYW 3H7D 4DMY 4DMX 1MEM 1BGO 1AU4 3O1G 1AYU 1AU0 1AU3 1AYV 2BDL 3OVZ 1NL6 3C9E 3KWB 1ATK 1Q6K 2AUX 1YT7 2AUZ 3KX1
DrugBank ID
BioGrid ID 107893
GuidetoPHARMACOLOGY ID 2350
PharmGKB ID PA27034
KEGG ID hsa:1513
DIP ID DIP-39993N
STRING ID 9606.ENSP00000271651
IntAct ID P43235
DMDM 1168793
BRENDA 3.4.22.38
Reactome R-HSA-1592389 R-HSA-1679131 R-HSA-1442490 R-HSA-1474228 R-HSA-2132295
SignaLink
BioCyc
Entrez Gene (Gene ID) 1513
BindingDB P43235

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.856 0.005 0.884 0.000 0.870 0.000 0.867 0.005 0.940 0.000 0.737 0.005 Download
Estate fingerprints 0.910 0.000 0.846 0.000 0.878 0.004 0.880 0.000 0.940 0.000 0.754 0.005 Download
MACCS fingerprints 0.751 0.003 0.869 0.000 0.810 0.000 0.800 0.000 0.890 0.000 0.630 0.000 Download
Daylight fingerprints 0.774 0.005 0.776 0.000 0.775 0.005 0.775 0.005 0.830 0.000 0.550 0.000 Download
ECFP2 fingerprints 0.970 0.000 0.950 0.004 0.960 0.000 0.960 0.000 0.990 0.000 0.919 0.003 Download
ECFP4 fingerprints 0.960 0.000 0.970 0.000 0.965 0.005 0.965 0.005 0.990 0.000 0.930 0.000 Download
ECFP6 fingerprints 0.941 0.003 0.979 0.003 0.960 0.000 0.960 0.000 0.990 0.000 0.919 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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