TargetNet
  Target name

P43681: Neuronal acetylcholine receptor subunit alpha-4

  Protein function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.

  Database links
Uniprot primary ID P43681
PDB ID 2LLY 2GVT
DrugBank ID DB00898 DB00514 DB01352 DB01353 DB00674 DB00312 DB00184
BioGrid ID 107559
GuidetoPHARMACOLOGY ID 465
PharmGKB ID PA26490
KEGG ID hsa:1137
DIP ID
STRING ID 9606.ENSP00000359285
IntAct ID P43681
DMDM 1351848
BRENDA
Reactome R-HSA-629587 R-HSA-629597 R-HSA-629594
SignaLink
BioCyc
Entrez Gene (Gene ID) 1137
BindingDB P43681
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.894 0.012 0.978 0.006 0.936 0.008 0.933 0.011 0.980 0.000 0.875 0.015 Download
Estate fingerprints 0.874 0.007 0.886 0.005 0.880 0.005 0.877 0.007 0.950 0.000 0.759 0.012 Download
MACCS fingerprints 0.866 0.013 0.910 0.009 0.888 0.006 0.886 0.010 0.978 0.004 0.779 0.017 Download
Daylight fingerprints 0.763 0.011 0.813 0.000 0.788 0.006 0.785 0.005 0.857 0.005 0.583 0.011 Download
ECFP2 fingerprints 0.893 0.009 0.951 0.008 0.922 0.008 0.922 0.008 0.980 0.000 0.848 0.014 Download
ECFP4 fingerprints 0.965 0.007 0.967 0.009 0.966 0.005 0.966 0.005 0.990 0.000 0.928 0.012 Download
ECFP6 fingerprints 0.963 0.013 0.973 0.005 0.968 0.006 0.968 0.006 0.990 0.000 0.929 0.013 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn