Target name

P45452: Collagenase 3


  Protein function

Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.

  Database links

Uniprot primary ID P45452
PDB ID 3ELM 1UC1 3LJZ 3O2X 1FLS 3I7I 1EUB 3TVC 3I7G 2PJT 456C 2E2D 1FM1 2OZR 4JPA 1ZTQ 4L19 3ZXH 4FVL 3WV1 3WV2 3WV3 4JP4 1XUR 5BPA 4G0D 5BOY 3KEK 3KEJ 5BOT 1XUC 1XUD 3KEC 2D1N 4FU4 1YOU 830C 4A7B 2OW9 2YIG 3KRY 1PEX
DrugBank ID DB00786
BioGrid ID 110465
GuidetoPHARMACOLOGY ID 1637
PharmGKB ID PA30871
KEGG ID hsa:4322
DIP ID
STRING ID 9606.ENSP00000260302
IntAct ID
DMDM 1168998
BRENDA 3.4.24.B4 3.4.24.17 3.4.24.65 3.4.24.35
Reactome R-HSA-1592389 R-HSA-2022090 R-HSA-1474228 R-HSA-1442490
SignaLink
BioCyc
Entrez Gene (Gene ID) 4322
BindingDB P45452

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.790 0.000 0.938 0.000 0.864 0.005 0.850 0.000 0.930 0.000 0.740 0.000 Download
Estate fingerprints 0.785 0.005 0.857 0.000 0.821 0.003 0.818 0.004 0.910 0.000 0.650 0.000 Download
MACCS fingerprints 0.780 0.000 0.860 0.000 0.820 0.000 0.813 0.005 0.930 0.000 0.650 0.000 Download
Daylight fingerprints 0.690 0.000 0.968 0.000 0.829 0.003 0.800 0.000 0.930 0.000 0.679 0.003 Download
ECFP2 fingerprints 0.890 0.000 0.958 0.000 0.924 0.005 0.920 0.000 0.980 0.000 0.850 0.000 Download
ECFP4 fingerprints 0.920 0.000 0.980 0.005 0.950 0.000 0.950 0.000 0.980 0.000 0.900 0.000 Download
ECFP6 fingerprints 0.890 0.000 0.976 0.000 0.933 0.005 0.930 0.000 0.980 0.000 0.871 0.003 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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