Target name

P45984: Mitogen-activated protein kinase 9


  Protein function

Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692).

  Database links

Uniprot primary ID P45984
PDB ID 3NPC 3E7O
DrugBank ID
BioGrid ID 111587
GuidetoPHARMACOLOGY ID 1497
PharmGKB ID PA30630
KEGG ID hsa:5601
DIP ID DIP-281N;DIP-270N
STRING ID 9606.ENSP00000389338
IntAct ID P45984
DMDM 85700366
BRENDA 2.7.11.24
Reactome R-HSA-2871796 R-HSA-450321 R-HSA-450341 R-HSA-2559580
SignaLink P45984
BioCyc
Entrez Gene (Gene ID) 5601
BindingDB P45984

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.799 0.007 0.861 0.007 0.830 0.005 0.827 0.005 0.920 0.000 0.664 0.008 Download
Estate fingerprints 0.822 0.008 0.786 0.004 0.804 0.005 0.806 0.007 0.880 0.000 0.608 0.012 Download
MACCS fingerprints 0.831 0.006 0.749 0.004 0.790 0.005 0.797 0.005 0.880 0.000 0.582 0.008 Download
Daylight fingerprints 0.844 0.008 0.786 0.006 0.815 0.005 0.819 0.003 0.880 0.000 0.630 0.007 Download
ECFP2 fingerprints 0.918 0.004 0.882 0.005 0.900 0.000 0.900 0.000 0.960 0.000 0.803 0.005 Download
ECFP4 fingerprints 0.884 0.005 0.952 0.005 0.918 0.004 0.916 0.005 0.969 0.003 0.840 0.008 Download
ECFP6 fingerprints 0.868 0.004 0.986 0.000 0.927 0.005 0.921 0.003 0.960 0.000 0.858 0.006 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn