Details-Calcnet-TargetNet

Target name

P47820: Angiotensin-converting enzyme

Protein function

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This GPIase activity seems to be crucial for the egg-binding ability of the sperm (By similarity).

Database links

Uniprot primary ID	P47820
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID	1613
PharmGKB ID
KEGG ID	rno:24310
DIP ID
STRING ID	10116.ENSRNOP00000010627
IntAct ID
DMDM
BRENDA	3.4.15.1
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID)	24310
BindingDB	P47820

Model Performance Metrics

Fingerprint type	Sensitivity	SEN_std	Specificity	SPE_std	Accuracy	ACC_std	F1-score	F1-score_std	AUC	AUC_std	MCC	MCC_std	Download model
FP2 fingerprints	0.979	0.003	0.941	0.008	0.960	0.000	0.965	0.005	0.980	0.000	0.925	0.007	Download
Estate fingerprints	0.980	0.000	0.882	0.006	0.931	0.003	0.939	0.003	0.980	0.000	0.870	0.005	Download
MACCS fingerprints	0.960	0.000	0.924	0.005	0.942	0.004	0.942	0.004	0.985	0.005	0.884	0.005	Download
Daylight fingerprints	0.897	0.007	0.929	0.005	0.913	0.005	0.912	0.004	0.960	0.000	0.832	0.008	Download
ECFP2 fingerprints	0.990	0.000	0.950	0.008	0.970	0.000	0.970	0.000	1.000	0.000	0.944	0.005	Download
ECFP4 fingerprints	0.990	0.000	0.950	0.005	0.970	0.000	0.970	0.000	0.999	0.003	0.944	0.005	Download
ECFP6 fingerprints	0.987	0.005	0.971	0.004	0.979	0.003	0.979	0.003	0.990	0.000	0.954	0.005	Download

Download datasets

Positive dataset

Negative dataset