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E-mail: biomed@csu.edu.cn
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Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This GPIase activity seems to be crucial for the egg-binding ability of the sperm (By similarity).
| Uniprot primary ID | P47820 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 1613 |
| PharmGKB ID | |
| KEGG ID | rno:24310 |
| DIP ID | |
| STRING ID | 10116.ENSRNOP00000010627 |
| IntAct ID | |
| DMDM | |
| BRENDA | 3.4.15.1 |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 24310 |
| BindingDB | P47820 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.979 | 0.003 | 0.941 | 0.008 | 0.960 | 0.000 | 0.965 | 0.005 | 0.980 | 0.000 | 0.925 | 0.007 | Download |
| Estate fingerprints | 0.980 | 0.000 | 0.882 | 0.006 | 0.931 | 0.003 | 0.939 | 0.003 | 0.980 | 0.000 | 0.870 | 0.005 | Download |
| MACCS fingerprints | 0.960 | 0.000 | 0.924 | 0.005 | 0.942 | 0.004 | 0.942 | 0.004 | 0.985 | 0.005 | 0.884 | 0.005 | Download |
| Daylight fingerprints | 0.897 | 0.007 | 0.929 | 0.005 | 0.913 | 0.005 | 0.912 | 0.004 | 0.960 | 0.000 | 0.832 | 0.008 | Download |
| ECFP2 fingerprints | 0.990 | 0.000 | 0.950 | 0.008 | 0.970 | 0.000 | 0.970 | 0.000 | 1.000 | 0.000 | 0.944 | 0.005 | Download |
| ECFP4 fingerprints | 0.990 | 0.000 | 0.950 | 0.005 | 0.970 | 0.000 | 0.970 | 0.000 | 0.999 | 0.003 | 0.944 | 0.005 | Download |
| ECFP6 fingerprints | 0.987 | 0.005 | 0.971 | 0.004 | 0.979 | 0.003 | 0.979 | 0.003 | 0.990 | 0.000 | 0.954 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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