Target name

P47820: Angiotensin-converting enzyme


  Protein function

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This GPIase activity seems to be crucial for the egg-binding ability of the sperm (By similarity).

  Database links

Uniprot primary ID P47820
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 1613
PharmGKB ID
KEGG ID rno:24310
DIP ID
STRING ID 10116.ENSRNOP00000010627
IntAct ID
DMDM
BRENDA 3.4.15.1
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 24310
BindingDB P47820

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.979 0.003 0.941 0.008 0.960 0.000 0.965 0.005 0.980 0.000 0.925 0.007 Download
Estate fingerprints 0.980 0.000 0.882 0.006 0.931 0.003 0.939 0.003 0.980 0.000 0.870 0.005 Download
MACCS fingerprints 0.960 0.000 0.924 0.005 0.942 0.004 0.942 0.004 0.985 0.005 0.884 0.005 Download
Daylight fingerprints 0.897 0.007 0.929 0.005 0.913 0.005 0.912 0.004 0.960 0.000 0.832 0.008 Download
ECFP2 fingerprints 0.990 0.000 0.950 0.008 0.970 0.000 0.970 0.000 1.000 0.000 0.944 0.005 Download
ECFP4 fingerprints 0.990 0.000 0.950 0.005 0.970 0.000 0.970 0.000 0.999 0.003 0.944 0.005 Download
ECFP6 fingerprints 0.987 0.005 0.971 0.004 0.979 0.003 0.979 0.003 0.990 0.000 0.954 0.005 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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