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E-mail: biomed@csu.edu.cn
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G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
| Uniprot primary ID | P47871 |
| PDB ID | 2A83 4ERS 4L6R 4LF3 3CZF |
| DrugBank ID | DB00040 |
| BioGrid ID | 108912 |
| GuidetoPHARMACOLOGY ID | 251 |
| PharmGKB ID | PA28607 |
| KEGG ID | hsa:2642 |
| DIP ID | |
| STRING ID | 9606.ENSP00000383558 |
| IntAct ID | P47871 |
| DMDM | 1346144 |
| BRENDA | |
| Reactome | R-HSA-418555 R-HSA-420092 R-HSA-416476 R-HSA-163359 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 2642 |
| BindingDB | P47871 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.923 | 0.005 | 0.957 | 0.005 | 0.940 | 0.000 | 0.940 | 0.000 | 0.974 | 0.005 | 0.883 | 0.005 | Download |
| Estate fingerprints | 0.774 | 0.005 | 0.780 | 0.008 | 0.777 | 0.005 | 0.777 | 0.005 | 0.875 | 0.005 | 0.552 | 0.010 | Download |
| MACCS fingerprints | 0.836 | 0.005 | 0.882 | 0.003 | 0.859 | 0.003 | 0.856 | 0.005 | 0.940 | 0.000 | 0.719 | 0.006 | Download |
| Daylight fingerprints | 0.838 | 0.006 | 0.954 | 0.000 | 0.896 | 0.005 | 0.889 | 0.006 | 0.958 | 0.004 | 0.796 | 0.008 | Download |
| ECFP2 fingerprints | 0.920 | 0.005 | 0.960 | 0.000 | 0.940 | 0.000 | 0.940 | 0.000 | 0.990 | 0.000 | 0.888 | 0.004 | Download |
| ECFP4 fingerprints | 0.961 | 0.003 | 0.999 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 0.990 | 0.000 | 0.954 | 0.005 | Download |
| ECFP6 fingerprints | 0.926 | 0.005 | 0.994 | 0.000 | 0.960 | 0.000 | 0.960 | 0.000 | 0.990 | 0.000 | 0.926 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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