Target name

P47871: Glucagon receptor


  Protein function

G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.

  Database links

Uniprot primary ID P47871
PDB ID 2A83 4ERS 4L6R 4LF3 3CZF
DrugBank ID DB00040
BioGrid ID 108912
GuidetoPHARMACOLOGY ID 251
PharmGKB ID PA28607
KEGG ID hsa:2642
DIP ID
STRING ID 9606.ENSP00000383558
IntAct ID P47871
DMDM 1346144
BRENDA
Reactome R-HSA-418555 R-HSA-420092 R-HSA-416476 R-HSA-163359
SignaLink
BioCyc
Entrez Gene (Gene ID) 2642
BindingDB P47871

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.923 0.005 0.957 0.005 0.940 0.000 0.940 0.000 0.974 0.005 0.883 0.005 Download
Estate fingerprints 0.774 0.005 0.780 0.008 0.777 0.005 0.777 0.005 0.875 0.005 0.552 0.010 Download
MACCS fingerprints 0.836 0.005 0.882 0.003 0.859 0.003 0.856 0.005 0.940 0.000 0.719 0.006 Download
Daylight fingerprints 0.838 0.006 0.954 0.000 0.896 0.005 0.889 0.006 0.958 0.004 0.796 0.008 Download
ECFP2 fingerprints 0.920 0.005 0.960 0.000 0.940 0.000 0.940 0.000 0.990 0.000 0.888 0.004 Download
ECFP4 fingerprints 0.961 0.003 0.999 0.000 0.980 0.000 0.980 0.000 0.990 0.000 0.954 0.005 Download
ECFP6 fingerprints 0.926 0.005 0.994 0.000 0.960 0.000 0.960 0.000 0.990 0.000 0.926 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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