This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.
| Uniprot primary ID | P47898 |
| PDB ID | |
| DrugBank ID | DB00408 DB00334 DB06216 |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 10 |
| PharmGKB ID | PA29558 |
| KEGG ID | hsa:3361 |
| DIP ID | |
| STRING ID | 9606.ENSP00000287907 |
| IntAct ID | |
| DMDM | 1345607 |
| BRENDA | |
| Reactome | R-HSA-418594 R-HSA-390666 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 3361 |
| BindingDB | P47898 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.774 | 0.010 | 0.974 | 0.000 | 0.874 | 0.007 | 0.856 | 0.005 | 0.943 | 0.005 | 0.760 | 0.012 | Download |
| Estate fingerprints | 0.841 | 0.007 | 0.839 | 0.016 | 0.840 | 0.011 | 0.839 | 0.009 | 0.920 | 0.000 | 0.680 | 0.018 | Download |
| MACCS fingerprints | 0.766 | 0.013 | 0.872 | 0.009 | 0.819 | 0.007 | 0.809 | 0.007 | 0.906 | 0.005 | 0.639 | 0.016 | Download |
| Daylight fingerprints | 0.799 | 0.007 | 0.833 | 0.003 | 0.816 | 0.005 | 0.814 | 0.005 | 0.850 | 0.000 | 0.631 | 0.011 | Download |
| ECFP2 fingerprints | 0.923 | 0.009 | 0.901 | 0.014 | 0.912 | 0.008 | 0.912 | 0.008 | 0.964 | 0.005 | 0.822 | 0.017 | Download |
| ECFP4 fingerprints | 0.936 | 0.008 | 0.900 | 0.007 | 0.918 | 0.006 | 0.919 | 0.007 | 0.970 | 0.000 | 0.837 | 0.011 | Download |
| ECFP6 fingerprints | 0.898 | 0.009 | 0.932 | 0.008 | 0.915 | 0.007 | 0.915 | 0.007 | 0.959 | 0.003 | 0.829 | 0.013 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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