Target name

P47898: 5-hydroxytryptamine receptor 5A


  Protein function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.

  Database links

Uniprot primary ID P47898
PDB ID
DrugBank ID DB00408 DB00334 DB06216
BioGrid ID
GuidetoPHARMACOLOGY ID 10
PharmGKB ID PA29558
KEGG ID hsa:3361
DIP ID
STRING ID 9606.ENSP00000287907
IntAct ID
DMDM 1345607
BRENDA
Reactome R-HSA-418594 R-HSA-390666
SignaLink
BioCyc
Entrez Gene (Gene ID) 3361
BindingDB P47898

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.774 0.010 0.974 0.000 0.874 0.007 0.856 0.005 0.943 0.005 0.760 0.012 Download
Estate fingerprints 0.841 0.007 0.839 0.016 0.840 0.011 0.839 0.009 0.920 0.000 0.680 0.018 Download
MACCS fingerprints 0.766 0.013 0.872 0.009 0.819 0.007 0.809 0.007 0.906 0.005 0.639 0.016 Download
Daylight fingerprints 0.799 0.007 0.833 0.003 0.816 0.005 0.814 0.005 0.850 0.000 0.631 0.011 Download
ECFP2 fingerprints 0.923 0.009 0.901 0.014 0.912 0.008 0.912 0.008 0.964 0.005 0.822 0.017 Download
ECFP4 fingerprints 0.936 0.008 0.900 0.007 0.918 0.006 0.919 0.007 0.970 0.000 0.837 0.011 Download
ECFP6 fingerprints 0.898 0.009 0.932 0.008 0.915 0.007 0.915 0.007 0.959 0.003 0.829 0.013 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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